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What an MLB source said about the Dbacks trade h

first_img What an MLB source said about the D-backs’ trade haul for Greinke RT @TDAVENPORT88: @mortreport What do u think Arizona will do w 5th pick? Any trade down rumors? > I’m now thinking Miller/Peterson/Quinnless than a minute ago via TweetDeck Favorite Retweet ReplyChris Mortensenmortreport Cardinals expect improving Murphy to contribute right away Comments   Share   Of course, their interest in Texas A&M’s Von Miller has been well documented, but LSU’s Patrick Peterson and North Carolina’s Robert Quinn have not been linked to the desert by too many people.ESPN’s Chris Mortensen knows a thing or two, though, and if he’s thinking the Cards are leaning towards one of those three it means the team must not be too enamored with the offensive players they expect to be available when their pick comes up. Or maybe they just want to improve a defense that ranked 29th in the NFL last season, allowing 27.1 points and 373.6 yards per game. D-backs president Derrick Hall: Franchise ‘still focused on Arizona’ Nevada officials reach out to D-backs on potential relocation Top Stories Much of the talk lately has been about the Cardinals perceived interest in Missouri QB Blaine Gabbert. Real or imagined, the idea of the Cards selecting a QB with the number five pick just more than a week from today is an exciting, if not a bit nerve-wracking, possibility. However, in true Helen Lovejoy fashion, the question has been posed: Won’t somebody please think of the defense?It appears the answer to that question may be yes.last_img read more

Tim Davie Profit and revenue have declined at BBC

first_imgTim DavieProfit and revenue have declined at BBC Worldwide in the wake of the sale of a chunk of the BBC America cable channel.The absence of a chunk of revenue from BBC America, 49.9% of which was sold to AMC for US$200 million (€180 million) earlier this year, caused the year-on-year revenue and profit reverses the commercial arm of the BBC said this morning.Headline 2014/15 revenues of £1 billion (€1.4 billion) were down 3.9% and headline profit decreased 11.9%, taking the annual total to £138.6 million. Worldwide said the declines were caused by the absence of BBC America revenues for most of the second half of the year.Comparing like for like revenues across its ongoing operations, it said there was a 0.4% increase in the £948 million recorded, and a 4.1% hike in profit of £127.1 million. Digital sales, advertising revenue across its channels and the contribution of UKTV were cited as key drivers.BBC Worldwide CEO Tim Davie said the AMC-BBC America deal “significantly enhanced future prospects for our BBC America channel, while also enabling us to boost shareholder returns for the year”.The proceeds of the AMC deal helped Worldwide generate a record amount of cash for the BBC, with an annual increase of 30.3%, taking the return to the Corporation to £226.5 million. Worldwide also contributed a greater amount in commissioning spend, becoming a production or distribution partner on various BBC shows, and in turn funding, or deficit-funding, a chunk of their budget.Reacting to the 2014/15 annual report, which was published today, BBC director general Tony Hall (pictured left, above) said it was a year of “positive progress at BBC Worldwide” against a “backdrop of market transformation that presented some challenges”.Hailing Worldwide the most successful commercial arm of any pubcaster in the world, he added that the Corporation wants it to return a cumulative £1 billion across the next five years.“Although commercial returns are a small part of the BBC’s funding mix, we are nonetheless determined to maximise their impact,” Hall said. “Therefore, looking ahead to the next phase of the BBC’s development, and a new charter period, it is the board’s aim to sustain annual financial returns at around this new level, even without the one-off benefit of BBC America proceeds.“We are therefore looking to BBC Worldwide to generate around £1 billion in returns for the Corporation in the five years starting from 2014/15 – an increase of almost one quarter on the previous half-decade.”Tim Davie (right) said that the business had “taken steps to drive innovation and underpin the sustainability” in the 2014/15 reporting period including investing in indies and relaunching its channel offering. “This is essential work in the context of a global media market undergoing structural and systemic changes, some of which constrain our trading and outlook in certain areas,” he said.In its last report, Worldwide reported a downturn in US sales. In its latest annual update said digital sales eclipsed linear for the first time in North America. Overall regional sales were £299.9 million compared to £342.5 million a year earlier. Profit was £32.9 million against £44.3 million across the same period.In the UK, headline 2014/2015 sales were £361.8 million compared with £362.2 million a year earlier and profit was £52.7 million against £56.2 million.There was growth in terms of Worldwide’s Australia and New Zealand business with 2014/15 revenues of £81.9 million compared to £76 million in 2013/14. Profit was £16.3 million against £13.3 million a year earlier.last_img read more

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first_imgSponsor Advertisement I’m only speculating here, but I would guess that JPMorgan et al were covering short position like mad in all precious metals yesterdayWell, that little uptick shortly before 10:00 a.m. in London yesterday morning turned out to be the high of the day for gold.  If it made it above the $1,600 spot level, it was only for a few seconds before the buyer[s] ran into an avalanche of selling from the usual not-for-profit suspects.It was all down hill from there, of course…but the gold price managed to open the Comex trading session in the black by a few bucks, but that lasted less than five minutes before the high-frequency traders showed up and began to engineer the price lower.The most ferocious part of the price decline started at 10:30 a.m. Eastern time…and in well under twenty minutes, the gold price cratered for another fifteen bucks.That proved to be the low the day at $1,570.70 spot…and from there a nice rally began that took the gold price back to over $1,592 spot.  But that was as high as it got…or was allowed to get…and the gold price slowly drifted lower until shortly before 4:00 p.m. Eastern time…and from there traded flat into the 5:15 p.m. electronic close.Gold finished the Tuesday session at $1,582.40 spot…down $6.20 from Monday.  It should come as no surprise that the volume figures for Tuesday were 50% higher than Monday’s, as net volume was around 129,000 contracts.It was precisely the same story in silver…except the price was more ‘volatile’.  Silver’s high…around $27.65 spot…came at the same time as gold’s…shortly before 10:00 a.m. in London.  Silver was still up about a dime at the Comex open until the high-frequency traders showed up at 9:40 a.m….and then again at 10:35 a.m. Eastern time.The low in silver [$26.68 spot] came at the same as gold’s low.  The subsequent rally took silver back above its Monday close and the Tuesday opening price on the Comex…and the New York high of the day.  But that wasn’t allowed to last, and silver closed the trading session at the same closing price as Monday…$27.31 spot.  What was the chance that that was a coincidence?  Net volume was also 50% higher than Monday’s volume…with 36,000 contracts traded vs. 23,000 contracts traded on Monday.The dollar index didn’t do a whole heck of a lot during Far East or London trading on Tuesday.  It was down about twenty basis points in early Far East trading…but then rallied back to basically unchanged by the 8:00 a.m. London open.  From there it more or less traded sideways until exactly 10:00 a.m. Eastern time, which also happened to coincide with the time of the London p.m. gold fix.Then, in the space of about forty minutes, the index rallied about 40 basis points.  The dollar index high tick just coincidentally happened to coincide with the low of both gold and silver in New York yesterday morning.From that high, the index got sold off…giving up all its gains and more by 4:00 p.m. Eastern time.  From there, the dollar index traded flat into the close, finishing the Tuesday trading session down about 15 basis points at 82.92.I’d like to say that yesterday’s sell-off in the precious metals was all currency related, but that certainly doesn’t explain the decline in both metals that began at 10:00 a.m. in London…and which continued right up until 10:00 a.m. in New York.  A large chunk of the dollar index rally was in the bag before either gold or silver got sold off hard…and it’s my opinion that they didn’t fall off the turnip truck at 10:30 a.m. Eastern on their own…they got pushed.The gold stocks actually spent a few minutes in the black after trading began in the equity markets in New York yesterday morning.  But that didn’t last too long..and from there they got sold off over two percent to their low at 10:40 a.m. Eastern time.  Then they rallied sharply until a few minutes after 12 o’clock noon…and then traded sideways from there.  The HUI finished down 0.97% on the day…and back below the 400 mark.There was the odd green arrow in the silver stocks yesterday…but they closed mostly down on the day…but Nick Laird’s Silver Sentiment Index actually finished the Tuesday trading day up 0.56%.  Considering the closing price of the seven big cap silver stocks that make up this index, I found this very hard to believe…and I told Nick that.(Click on image to enlarge)The CME’s Daily Delivery Report showed that 2 gold and 436 silver contracts were posted for delivery on Thursday.  The big shocker, at least for me, was that the big short/issuer was JPMorgan in its in-house/proprietary account.  They’re delivering 426 contracts.  The biggest long/stopper was the Bank of Nova Scotia with 324 contracts…along with 63 contracts for JPMorgan in its client account…and 43 contracts for ABN Amro.  The Issuers and Stoppers Report is definitely worth looking at…and the link is here.There were no reported changes in either GLD or SLV…and the U.S. Mint didn’t have a sales report either.Over at the Comex-approved depositories, they reported receiving 599,779 troy ounces of silver on Monday…and shipped 906,225 ounces of the stuff out the door.Ted Butler pointed out to me yesterday that Sprott’s Physical Silver Trust [PSLV/PHS.U] has already reported receiving around 5.2 million ounces of the silver that it had ordered.Here’s an e-mail that I received from reader Eddie Costik yesterday…and it’s pretty much self-explanatory…Ed…”I have news for you….the home industry in the U.S. is finished as we know it. Retail sales for home improvement were down 1.6% for the month of June. I’m still in touch with wholesale distributors of building materials…nobody in that industry is making any money. My small retail lumber company is only one of five remaining in a five county area of Central Pennsylvania. Everyone is struggling. The halcyon days from the past are over. Mortgage rates are at all time lows but very few can qualify because of stringent qualification requirements. There are so many foreclosures that banks are holding them off the market so they don’t have to write them down. If Obama gets his way…. eliminating the Bush tax cuts we’re headed for an economic abyss. Then again how much worse can it get? A lot. Hold onto your behind this is not going to end well.” It was a very slow news day yesterday, so I’m delighted to report that I don’t have much reading material for you…but there are quite a few of the ones that I do have, that are well worth your time.As investors begin to realize that gold has not peaked, and that today’s “high” prices are actually just a step on the way up, I expect more of them to pile into the gold sector. The pressure to find sectors and companies with a good return will send Main Street investors, Wall Street fund managers, and sovereign wealth funds into our market. The spectacle will be, as Doug Casey likes to say, like trying to pour the contents of the Hoover Dam through a garden hose. – Louis James, Senior Metals Investment Strategist, Casey ResearchThere’s not much one can say about yesterday’s price action in all the precious metals except to say that we’ve seen this particular movie lots of times in the past…an engineered price decline behind a manufactured rally in the dollar index.As I mentioned in my closing remarks in ‘The Wrap’ yesterday…Tuesday was the cut-off for Friday’s Commitment of Traders Report, so I was prepared for anything as far as price movement went…and this price pattern didn’t surprise me one bit.I’m only speculating here, but I would guess that JPMorgan et al were covering short position like mad in all precious metals yesterday…and going further on the long side as well in the subsequent rally, which had all the hallmarks of a short covering rally.  I am hopeful that all this price action will show up in Friday’s COT report…and it should be obvious to anyone that the ‘powers that be’ want gold below $1,600 spot for as long as possible.It was gratifying to see John Hathaway come out of the closet and state that ‘da boyz’ are obviously managing the gold price…just as they are managing the LIBOR.  I would suspect that Eric King will have the audio interview of that blog posted on this website sometime today…and I will be posting it this space as soon as it becomes available.Not much happened in Far East trading during their Wednesday…and it’s pretty much the same now that London is open.  Volume is light in both metals…and the dollar index is not doing a thing, either.I haven’t a clue as to how gold will trade during the Comex session in New York today, but one can assume that the worse the news, the lower the gold price will be engineered.  As to when the precious metal prices break higher, it’s 100% up to JPMorgan et al…and when they decide to end their duties as a not-for-profit seller, it will be immediately apparent in the price…and not a moment before.I hope that your Wednesday goes well…and I’ll see you tomorrow. Bayfield Ventures Corp. (TSX.V: BYV) is exploring for gold and silver in the Rainy River District of NW Ontario. The Company’s 100% owned “Burns” Block property adjoins the immediate east of Rainy River Resources’ (TSX.V: RR) world-class gold deposit which includes an indicated resource of 5.72 million ounces of gold, averaging 1.18 g/t, in addition to an inferred resource of 2.25 million ounces of gold, averaging 0.79 g/t. Drilling to date on Bayfield’s Burns Block demonstrates that the ODM17gold zone extends from Rainy River Resources’ ground onto the Burns Block. Bayfield is currently carrying out 100,000 metres of diamond drilling on its Rainy River properties. Drill results thus far have been very encouraging. Notable drill results include 60.05 grams per tonne gold and 362.96 grams per tonne silver over 11.2 metres within 26.70 grams per tonne gold and 170.69 grams per tonne silver over 25.5 metres, as well as 35.93 grams per tonne gold and 359.65 grams per tonne silver over 10.0 metres. Bayfield also holds a 100% interest in two other properties in the Rainy River District. Claim blocks “B” and “C” are well located to the immediate east and west (respectively) of Rainy River Resources’ #433 and ODM17 gold zones. Please visit our website to learn more about the company and request information.last_img read more

Fortyfive states and the Department of Justice ar

first_imgForty-five states and the Department of Justice are claiming that generic-drug prices are fixed and the alleged collusion may have cost U.S. business and consumers more than $1 billion.In their complaint, prosecutors say that when pharmacies asked drugmakers for their lowest price, the manufacturers would rig the bidding process.”The companies would work out in advance who would get the lowest price and then the other competitors may put in what we would call a cover bid,” says Michael Cole, who heads the antitrust department at the Connecticut attorney general’s office. (Such bids give the appearance of competitive bidding.)Through subpoenas, Cole’s team has assembled millions of texts, emails and phone calls between 2012 and 2015. The prosecutors say the records show executives divvying up customers, setting prices and giving the illusion that generic pharmaceuticals were transacted in an open and fair marketplace.Because of this price-fixing scheme, prosecutors say, health insurance premiums and copays increased. They also say tax-funded programs like Medicare and Medicaid overspent on drugs.So far, two executives from Heritage Pharmaceuticals have pleaded guilty to antitrust crimes. Both are now feeding information to prosecutors who say the two rigged prices on, among other drugs, the common antibiotic doxycycline, which shot the price up 8,000 percent.”To the extent that taxpayers have had to pay that bill, I think that the taxpayers should recover. And we will get involved on the civil side and recover damages for the U.S. government,” Makan Delrahim, head of the Department of Justice’s antitrust division, said at a seminar.The fact that the Department of Justice is involved has caught the attention of class-action lawyers.Jason Dubner, an attorney for Butler, Rubin, Saltarelli & Boyd, says the allegations are so massive that prices throughout the generic industry could have been affected. “You start to get an understanding just how widespread this alleged conspiracy was to cover so many different types of cures,” he says.Law firms that specialize in class actions have already lined up as many as 80 companies that may have paid too much, including retail pharmacies, employee unions and insurance companies. Dubner predicts more will join as the lawsuit progresses, perhaps even individual consumers.The pharmaceutical manufacturers named in the complaint have either declined to comment or denied the allegations, saying they have a robust compliance program.Ronny Gal, a market analyst for Sanford Bernstein, says on average, the generic-drug industry has lowered prices for consumers. But, he says, in an efficient marketplace, generic-drug wholesalers should have kept prices in check.”In a market that has only three or four really large distribution organizations, they are sometimes tempted to maximize their own profits in a way that does not always 100 percent reflect the best interest of their clients,” Gal says.This is what investigators are looking at now. In their complaint they suggest — but don’t allege — that the price-fixing conspiracy also involved drug distributors. Prosecutors are sending more subpoenas and planning a new complaint.”It could be more generic manufacturers, it could be more drugs, it could be more entities in the distribution chain. It could be all of that,” Cole, of the Connecticut attorney general’s office, says.A spokesperson for McKesson, one of the largest generics distributors, said the company is cooperating with requests for information from prosecutors and that it competes aggressively for the lowest price available.Based on what’s in the current lawsuit, Gal estimates an eventual settlement would be around $1 billion. But he says that number could go as high as $5 billion, especially if more drugs are included. Copyright 2018 WSHU. To see more, visit WSHU.last_img read more

A major medical association today suggested that d

first_imgA major medical association today suggested that doctors who treat people with Type 2 diabetes can set less aggressive blood sugar targets. But medical groups that specialize in diabetes sharply disagree.Half a dozen medical groups have looked carefully at the best treatment guidelines for the 29 million Americans who have Type 2 diabetes and have come up with somewhat differing guidelines.The American College of Physicians has reviewed those guidelines to provide its own recommendations, published in the Annals of Internal Medicine. It has decided that less stringent goals are appropriate for the key blood sugar test, called the A1C.”There are harms associated with overzealous treatment or inappropriate treatment focused on A1C targets,” says Dr. Jack Ende, president of the ACP. “And for that reason, this is not the kind of situation where the college could just sit back and ignore things.”The ACP, which represents internists, recommends that doctors aim for an A1C in the range of 7 to 8 percent, not the lower levels that other groups recommend.For people who have already achieved a lower level, “consider de-intensifying treatment,” Ende says. “That is, reducing one of the medications, stopping a medication, just allow the A1C to be between 7 and 8.”Some studies have shown that people who have aggressively pushed to lower their blood sugar are at somewhat higher risk of premature death. People also suffer from low blood sugar as a result of aggressive treatment.That was the case for Valerie Pennington, a special-needs teacher who lives in Odessa, Mo. She was diagnosed in her mid-40s and put on an aggressive treatment regime.”The nurse at school — because I was going low so much — made me get an alarm clock.” Otherwise, she says, she didn’t realize when she was about to faint. “At one point, one of the children actually had to save me because I had just zoned out.”Pennington also had trouble losing weight because one of the drugs she took for diabetes often leads to weight gain.The upside for her — and it’s a big one — is that once she was off that drug, she shed 100 pounds and has been able to keep her blood sugar in the normal range.She says her general-practice doctor wasn’t fixated on a particular number for her A1C, “but my ophthalmologist would always check the number because above 6.5 the chances of getting retinopathy grow.”People with elevated blood sugar risk more than their vision, says Dr. George Grunberger, who was on the committee that drew up diabetes guidelines for the American College of Endocrinologists and is past president of the American Association of Endocrinologists.”The moment your glucose goes above normal, it’s incurring damage to the back of the eye, to kidneys and to nerves, especially in your feet,” he says.Grunberger says he is stunned to see the American College of Physicians giving more weight to the risks of low blood sugar than the benefits of keeping it under control.”My concern is this will be a message to many practicing physicians saying, ‘Well, don’t worry about it so much, because it’s OK,’ ” he says.He is even more surprised by the suggestion to let a patient’s blood sugar levels rise if the A1C is below 7 percent. He says that is based on a misinterpretation of old studies conducted for purposes other than setting optimal blood sugar levels.The American Diabetes Association also rejects the ACP’s recommendation.”We stand by our guidelines,” says Dr. William Cefalu, chief scientific, medical and mission officer of the ADA.Cefalu says, for one thing, the new guidance gives short shrift to a new generation of drugs that are in use to control blood sugar, “and these drugs do have less risk for hypoglycemia [low blood sugar] and some have very favorable effects on body weight and other cardiovascular risk factors.”Everyone does agree on one thing: There is no one-size-fits-all solution.”These are recommendations,” Ende, the ACP president, says. “Your doctor should make a decision based upon his best information or her best information as well as your particular case.” Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

This Woman Just Made NFL History

first_imgLeadership Image credit: Al Bello | Getty Images Add to Queue 2 min read –shares Staff Writer. Covers leadership, media, technology and culture. This Woman Just Made NFL History Nina Zipkin This Sunday, during the matchup between the New England Patriots and the Los Angeles Chargers, NFL referee Sarah Thomas became the first woman to be an on-field official at an NFL playoff game. It wasn’t the first time that Thomas made football history.In 2015, she became the first female official hired by the NFL, and before her hiring in 2011, she was the first female official to work in a Big Ten stadium. In 2009, she was the first woman to officiate a college football bowl game, and in 2007, she was the first woman to work at a major college football game.Before her career as a football official, Thomas, a Mississippi native and married mom of three, was a college basketball star at the University of Mobile.Related: 4 Branding Lessons From Nike’s Colin Kaepernick AdAt the start of her NFL career, she shared with CBS News how her tenure as a scholar-athlete informed her career.”Maybe at times when they made a controversial call that I didn’t think was right, I voiced my opinion, but I think they would get just as aggravated with me at times, too,” Thomas told CBS. “When I started in football officiating, I had no idea the pride and the amount of time that they put into trying to get the game right.”On social media, Jennifer Welter, the NFL’s first female assistant coach, congratulated Thomas.Today my good friend Sarah Thomas will #kickglass and become the first woman to officiate a playoff game #football #footballfamily #womeninsports #grrridirongirls #legends @ San… https://t.co/8A93bSwLUt— Dr. Jen Welter (@jwelter47) January 13, 2019center_img Learn how to successfully navigate family business dynamics and build businesses that excel. Next Article January 14, 2019 Entrepreneur Staff Sarah Thomas became the first woman to be an on-field official at a playoff game. Free Webinar | July 31: Secrets to Running a Successful Family Business Register Now »last_img read more

Mobilizing VoIP

first_img Mobilizing VoIP Register Now » Add to Queue 2 min read Learn how to successfully navigate family business dynamics and build businesses that excel. Dan O’Shea Most small-business entrepreneurs are now well aware of the economic benefits and flexibility advantages of using VoIP for their office communications needs. Now, it’s time for lesson two: How to leverage VoIP’s benefits while on the go.A big-box retailer, hearty competitor to many a small business, may seem an unlikely teacher for this lesson. Yet, Best Buy is doing an increasingly good job of addressing the technology needs of its small-business customers. As part of the Best Buy for Business concept, the retailer operates its own national VoIP service provider­–Speakeasy­–catering to the small-business market.Speakeasy, based in Seattle, was already a nationally known VoIP service brand when Best Buy acquired it in 2007. Thousands of small businesses in the U.S. use Speakeasy Hosted Voice, and late last year, Speakeasy introduced the first mobile extension of its platform, targeted at iPhone users. EasyVoice Mobile for iPhone extends an existing Speakeasy customer’s wireline calling package, including a call management feature and free calling to more than 20 countries, to a device that has become standard issue to small-business owners.Call management functions run through Remote Office, an application that integrates with an iPhone contact list and allows iPhone users to make and receive calls via their desktop office phone number. Users can also hold, forward, access voice mail and do pretty much anything they would while at the office. “It gives the impression that you’re always available,” Chatterley said.He added that the big telecom companies still do a poor job of addressing evolving small-business calling needs, delivering cellular plans targeted at small firms, but not comprehensive applications covering both the fixed office and the mobile office. Ironically, a big-box retailer may teach them a lesson, too. Magazine Contributor Speakeasy takes the popular voice alternative on the road. Technology This story appears in the February 2010 issue of Entrepreneur. Subscribe » Next Article Free Webinar | July 31: Secrets to Running a Successful Family Business –shares January 15, 2010last_img read more

Cofounder of Chesapeake Energy Corp Dies in Car Accident

first_img Register Now » Reuters Next Article Co-founder of Chesapeake Energy Corp. Dies in Car Accident Add to Queue March 2, 2016 –shares Aubrey McClendon, the co-founder of Chesapeake Energy Corp who led it to become one of the world’s biggest natural gas producers before he was tarred by federal anti-trust charges, died on Wednesday in a car accident in Oklahoma City, police said. He was 56.McClendon died one day after the U.S. Department of Justice indicted him for allegedly violating antitrust laws by colluding to rig bids for oil and gas acreage while he was at Chesapeake, which has been a central player in the U.S. fracking revolution of the past decade. He denied the charges.McClendon resigned from Chesapeake in 2013 after a corporate governance crisis and investor concerns over his heavy spending.He went on to start American Energy Partners, and with the help of private equity funds, made huge bets on vast oil acreage around the United States and Australia.Police said they were investigating the cause of the crash that occurred when McClendon was driving his 2013 Chevy Tahoe. Police said the vehicle was so badly burned they were unable to tell if McClendon was wearing his seat belt.A native of Oklahoma, he attended Duke University before starting Chesapeake with his friend Tom Ward, who went on to lead SandRidge Energy Inc. for a time.”Chesapeake is deeply saddened by the news that we have heard today and our thoughts and prayers are with the McClendon family during this difficult time,” a Chesapeake spokesman said in a statement.(Reporting by Liz Hampton, Jessica Resnick Ault and Ernest Scheyder; Writing by Terry Wade; Editing by Leslie Adler) This story originally appeared on Reuters Death 2 min read Image credit: Sean Gardner | Reuters Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Chief Executive Officer, Chairman, and Co-founder of Chesapeake Energy Corporation Aubrey McClendon walks through the French Quarter in New Orleans, Louisiana March 26, 2012.last_img read more

Senators to Airlines Whats Up With the Computer Outages

first_img This story originally appeared on PCMag Senators to Airlines: What’s Up With the Computer Outages? Don Reisinger Register Now » 2 min read Next Article August 18, 2016 Contributing Writer Frequent fliers aren’t the only ones fed up with airline computer outages. In the wake of delays due to recent glitches with the systems of Southwest and Delta Air Lines, two US senators are asking for answers.”We are concerned with recent reports indicating that airlines’ IT systems may be susceptible to faltering because of the way they are designed and have been maintained,” Democratic Sens. Edward J. Markey of Massachusetts and Richard Blumenthal of Connecticut wrote in a letter to more than a dozen airlines. Delta flights were grounded earlier this month after “a critical power control module at our Technology Command Center malfunctioned, causing a surge to the transformer and a loss of power,” according to COO Gil West. Southwest, meanwhile, had to cancel hundreds of flights last month after its website went down.In their letters, Markey and Blumenthal “inquire about safeguards and backups in place within airline IT systems to protect against power outages, cyberattacks and other hazards,” they said in a statement. They also “ask the airlines about policies that would allow passengers to be rebooked on another airline or on a different mode of transportation in the event of irregular operations caused by the airlines, as well as about their reimbursement and compensation policies.”Airline mergers are not helping the situation, they continued. “Now that four air carriers control approximately 85 percent of domestic capacity, all it takes is one airline to experience an outage and thousands of passengers could be stranded, resulting in missed business meetings, graduations, weddings, funerals and other prepaid events.”The senators’ letter includes several queries, including how many times technology has caused an outage to air traffic, what safeguards are in place when systems fail, and the current state of the airline’s IT system. They have asked the airline CEOs to respond to their queries by Sept.16.Airlines that received the letter include American Airlines, Delta Airlines, Southwest Airlines, United Airlines, JetBlue Airways, Alaska Airlines, Spirit Airlines, Frontier Airlines, Hawaiian Airlines, Allegiant Air, Virgin America, Sun Country Airlines and Island Air Hawaii. Add to Queue Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Airlines Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals Image credit: Shutterstock –shareslast_img read more

QuanticMind Offers SEM Marketers Powerful New Automated Bidding Capabilities

first_imgQuanticMind announced its Spring 2019 product release, ushering in new functionality for digital marketers who are focused on achieving peak performance and optimization from paid search channels. The pioneering Martech company, based in Silicon Valley, has unlocked ways to automate highly valuable audience bid adjustments in Google Ads, optimize Bing Shopping campaigns using proprietary data science techniques, and launched a machine learning based forecasting module for SEM and Shopping campaigns. These new features together augment QuanticMind’s position as the leader in predictive digital advertising management.“We’ve focused on adding sophisticated machine learning algorithms to ensure better accuracy and increased reliability in driving optimal performance of paid search campaigns,” said QuanticMind’s CEO, Chaitanya Chandrasekar. “These updates represent only the beginning of the journey we’re on to deliver a solution that enables digital marketers to solve paid advertising challenges at far greater scale, faster speed, and at deeper levels of granularity than previously possible.”QuanticMind has committed to continually engage in product improvements to help digital marketers achieve their performance goals. This Spring release adds another chapter by delivering features that directly empower SEM marketers to optimize their marketing campaigns for the best ROI.Marketing Technology News: Pandora Selects OpenText’s Digital Asset Management Platform for Streaming AdvertisingThe highlight of the Spring 2019 release is the launch of Automated Audience Bid Adjustments for Google Ads. Sophisticated marketers understand the power of showcasing their ads to targeted audiences: who they are, their interests and habits, what they are actively researching, or how they have interacted with businesses in the past. The QuanticMind platform dynamically automates how marketers manage audiences in Google Ads by drawing on the historical performance of audience segments to set optimal audience bid adjustments. This new bidding model ultimately ensures that marketers are minimizing wasted advertising spend and maximizing their business returns by reaching the right people, with the right message, at precisely the right moment.The second major capability rolled out is an advanced Forecasting Module. By taking in auction insights data, bid landscape models, historical performance trends, and seasonality factors, QuanticMind can now predict performance for up to 100 days in the future of paid search campaigns. By surfacing such critical insights in advance, marketers are empowered to determine what ROAS, Margin or CPA targets need to be set to achieve specific performance goals. Furthermore, channel budget shifts can be handled much more effectively with the guesswork eliminated.Marketing Technology News: Pitney Bowes and Accenture Team to Help Clients Take Advantage of Intelligent, Data-Driven SolutionsRounding out the trio of major features is Bing Shopping Optimization. Now, the same powerful machine learning algorithms that QuanticMind applies to Google Shopping campaigns can be employed to drive better investments on Bing Shopping. Strategies and reporting across the two publishers sit directly in one source of truth, allowing for a holistic overview of performance. QuanticMind Shopping continues to support feed management for both the Google and Bing Merchant Centers.The future of search engine marketing is bright as new levels of performance optimization become possible through QuanticMind’s Spring 2019 Release.Marketing Technology News: Elastic Stack 7.0 Now Available QuanticMind Offers SEM Marketers Powerful New Automated Bidding Capabilities PRNewswireApril 16, 2019, 5:44 pmApril 16, 2019 Audience Bid AdjustmentsChaitanya ChandrasekarGoogle AdsMarketing TechnologyNewsQuanticMindSEM Previous ArticleHG Insights Partners with Forrester to Expand Worldwide Technology Adoption CoverageNext ArticleEngageya Launches “Stories” Unit For Mobile Publisherslast_img read more

Highspot Launches Sales Enablement Industrys First Program to Provide Direct Access to

first_imgChallenger, CustomerCentric Selling, DSG Consulting, RAIN Group, and ValueSelling Now Offer Exclusive Content to Highspot Customers Directly in the Highspot PlatformHighspot, the modern sales enablement solution that sales reps love, announced the launch of its Sales Acceleration Partners program. This first-of-its-kind global program combines unparalleled sales and marketing expertise with the industry’s number one customer-rated sales enablement technology. Customers will have access to exclusive content and guidance directly within the Highspot platform from world-class go-to-market experts including Challenger, CustomerCentric Selling, DSG Consulting, RAIN Group, and ValueSelling.Marketing Technology News: Userful Announces New Drag-and-Drop Command and Control Module for Visual Networking PlatformBuilt on Highspot’s industry-first Spots and SmartPage technologies, the new program will give Highspot customers direct access to partner expertise and content within their daily workflow. Highspot Sales Acceleration Partners specialize in services that modernize traditional selling and go-to-market approaches from sales enablement best practices, to sales methodology, sales training, and sales playbooks.“To meet the needs of today’s modern buyer, companies in every industry are in the midst of transforming both their sales methodology and technology, ” said Robert Wahbe, Highspot co-founder and CEO.  “Our new program brings the brightest thinking in sales and marketing strategy directly into Highspot, filling a clear market need and giving our customers an unmatched competitive advantage.”Marketing Technology News: Sales Engagement Leader Outreach Reaches Unicorn Status, Raises $114 Million Series E“Organizations that enable a Challenger approach are more likely to grow and deliver real customer impact,” said Simon Frewer, Challenger’s CEO. “However, full adoption and sustainment take time and effort, especially at scale. Highspot’s unique ability to drive rapid, organization-wide adoption of core strategies and behaviors ensures sales reps can easily access content developed around Challenger best practices within the sales enablement platform that they already know and love.”Marketing Technology News: PCM Partners with RingCentral to Bring Cloud Communications Solutions to Enterprises Highspot Launches Sales Enablement Industry’s First Program to Provide Direct Access to Leading Sales Methodology MTS Staff WriterApril 24, 2019, 6:41 pmApril 24, 2019 CustomerCentric SellingHighspotMarketing TechnologyNewsRobert WahbeSales Acceleration PartnersSales Enablement Previous ArticleRFPIO Leads Way to Faster, More Accurate Responses with Patented Document Import, Export FunctionalityNext ArticleHootsuite Named a Leader in Sales Social Engagement Tools Report by Independent Research Firmlast_img read more

Code Pilot Approved as a Microsoft AI Inner Circle Partner

first_imgBiscuitville Fresh Southern is a family-owned restaurant chain that serves authentic Southern cooking that’s fresh, scratch-made and uses locally sourced ingredients. Biscuitville sets itself apart from the competition by being a brand that is rooted in Southern hospitality, with traditional recipes that are modern and unexpected. However, the company recognizes that, when it comes to location intelligence, it was time for a cutting-edge technology upgrade.With SiteZeus’ AI-powered location intelligence platform, Biscuitville can leverage the power of real-time data insights to help plan for future success in its multi-unit growth. Biscuitville currently operates 55 restaurants in North Carolina and Virginia. “Biscuitville has a long history of serving great food, and SiteZeus is excited to bring its state-of-the-art location intelligence platform to help the company better understand its store performance at a more granular level,” said Robert Cherrington, Executive Vice President of Sales at SiteZeus. “One of the factors that influenced the company’s decision was our ability to quickly create a highly accurate proof of concept to give Biscuitville a taste for what we can do.”Biscuitville provided SiteZeus with about a dozen site-specific attributes and revenue data for its 55 restaurant portfolio. SiteZeus then layered on the additional market and competitor data from The Olympus Data Exchange, to deliver a highly accurate proof of concept model with detailed insights into existing and potential store performance – delivered all in under three hours. Instantly, Biscuitville was able to see which data points were impacting individual store performance, both negatively and positively, to best duplicate success.Biscuitville plans to use the SiteZeus platform to improve performance at existing stores, as well as analyze the viability of future store locations. “This model allows us to determine with a higher level of confidence what key attributes drive sales and bottom-line revenue. The data intelligence provided by SiteZeus provides us with information that will assist us in making enhanced decisions when it comes to new site locations, relocations and rebuilds of existing restaurants, and cannibalization modeling,” said Kevin Bennett, Chief Financial Officer at Biscuitville Fresh Southern Code Pilot Accelerates Enterprise AI Projects With Their Intelligent PlatformCode Pilot Corp – a leader in AI enablement and acceleration solutions, announced it was approved by Microsoft as an AI Inner Circle Partner. Microsoft’s AI Inner Circle Partner Program recognizes Microsoft Partners who can transform a customer’s business by accelerating the deployment of AI based projects.“Acceptance into the Microsoft AI Inner Circle Partner Program requires demonstrated expertise in AI and is only offered to companies with the proven ability to support Microsoft customers in designing, developing and deploying intelligent solutions. We’re pleased to have Code Pilot join this group of Microsoft Partners.”he AI Inner Circle Partner Program is designed for partners with demonstrated expertise in the area of AI. Code Pilot’s reputation as a thought leader and elite group of Applied Data Scientists provides customers with a low-risk method for developing intelligent products on Microsoft Azure, bringing together the joint benefits of Cloud + AI.“Being selected as a Microsoft AI Inner Circle Partner is a huge endorsement of our platform,” said David Lemphers, CEO of Code Pilot. “As enterprise organizations look to improve the success of their AI initiatives, we can help them reduce risk and increase ROI by 20% on average.”Marketing Technology News: Swiftpage Launches All-in-One Act! Growth Suite Sales & Marketing Platform for SMBsLindsey Allen, Director of Product Management, Microsoft AI platform said, “Acceptance into the Microsoft AI Inner Circle Partner Program requires demonstrated expertise in AI and is only offered to companies with the proven ability to support Microsoft customers in designing, developing and deploying intelligent solutions. We’re pleased to have Code Pilot join this group of Microsoft Partners.”Marketing Technology News: 4INFO Adds Smart TV Data Through Partnership with InscapeCode Pilot’s AI AcceleratorsTime and skills are the primary factors leading to the failure of enterprise AI initiatives. Code Pilot mitigates these risks by providing customers with a platform for solving business needs faster and without the burden of hiring a dedicated ML team.Leveraging their extensive experience developing and deploying production grade AI solutions for Fortune 500 customers, Code Pilot’s platform ensures customers don’t get stuck in the envisioning phase and instead move rapidly to the deployment and operations phase. This is crucial to successful AI-driven business transformation.Marketing Technology News: New Data: Facebook and Google Trounce Amazon for D2C Brand Ad Spend acceleration solutionsAIAI Inner Circle PartnerDavid LemphersMarketing TechnologyMicrosoftNews Previous ArticleNikon Video Contest Challenges Creators To “Follow Your Passion” For A Chance To Win $25,000 And A Nikon Z 6 Filmmaker’s KitNext ArticleAdomni and Lightbox OOH Video Network Partner to Drive New Programmatic Revenue for Shopping Mall Screens,Code Pilot Approved as a Microsoft AI Inner Circle Partner Chandni MaskeMay 17, 2019, 8:00 pmMay 17, 2019 Previous ArticleYes Marketing Joins Forces with Adobe to Provide Leading Technology Combined with White Glove Agency, Implementation, and Program Management ServicesNext ArticleNikon Video Contest Challenges Creators To “Follow Your Passion” For A Chance To Win $25,000 And A Nikon Z 6 Filmmaker’s Kit Code Pilot Approved as a Microsoft AI Inner Circle Partner PRNewswireMay 17, 2019, 8:23 pmMay 17, 2019 last_img read more

VClick Technology Officially Launched

first_imgV-Click Technology Officially Launched Globe Newswire1 day agoJuly 22, 2019 digital marketingiClickMarketing Technology NewsNewsSammy HsiehV-Click TechnologyYan Lee Previous ArticleAsia-Pacific Managed Security Service Providers Need to Offer Advanced Analytics to Drive Growth Opportunities in the region, finds Frost & SullivanNext ArticleRoundtable Series: The Benefits of AI for Retail Operations Technology-driven marketing solutions for Southeast Asian companies to target and capture China’s lucrative consumer marketV-Click Technology (“V-Click”), the joint venture formed between VGI Global Media Plc, Thailand’s number one online to offline (O2O) solutions provider across advertising, payment and logistics platforms and iClick Interactive Asia Group Limited, (“iClick”) (NASDAQ: ICLK), an independent online marketing and enterprise data solutions provider in China, is officially launched.The suite of technology-driven digital marketing and media solutions provided by V-Click will include intelligence, social, and mobile tools based on iClick’s 825 million1 consumer profiles to provide clients with a comprehensive insight into the Chinese market. V-Click will also continue to launch various products and applications that extend the joint data and technological capabilities of iClick and VGI, including marketing SaaS solutions and AI-powered mobile applications, among others.Marketing Technology News: WebCEO, the Agency Oriented Marketing Platform, Launches a New Local SEO ModuleThailand is one of the most popular overseas destinations for Chinese tourists. According to the Ministry of Tourism and Sports in Thailand, in 2018 there were 10.5 million visitors from China, with a total expenditure of THB 580 billion. Chinese visitors are the top source of foreign receipts in an industry that makes up about a fifth of the Thai economy, presenting significant opportunity to Thai brands to reach this audience.Leveraging the respective digital strengths and extensive local networks of iClick and VGI, V-Click will help companies in the region deepen their engagement with the lucrative audience of Chinese outbound travellers and consumer groups through targeted and customized strategies as well as market leading solutions that consider the unprecedented cross-border retail opportunities.To celebrate V-Click’s launch, VGI and iClick co-hosted an industry event in Bangkok that provided insights on digital marketing in China, attended by over 300 marketers from Thailand. Leading Chinese internet players and marketing experts including Tencent, Ctrip, RED and DianPing shared their insights on China’s outbound tourism market and the purchasing behaviour of Chinese outbound travellers.Marketing Technology News: Progress Named a Leader in the New 2019 Gartner Magic Quadrant for Multiexperience Development Platforms“Advanced marketing technology has become an essential tool to help Southeast Asian consumer brands who are looking to penetrate Chinese travellers. V-Click is uniquely positioned to help Southeast Asian companies to reach Chinese consumer markets and convert marketing efforts to real business value, backed by the region’s two leading marketing solutions players,” commented Yan Lee, Chief Product Officer of iClick and Chief Executive Officer of V-Click.“As announced in June, VGI’s strategic investment in iClick further expands the ongoing collaboration between the two companies and this move demonstrates the confidence the two parties have in the synergies they can create and the market opportunities of which they are looking to take advantage,” said Sammy Hsieh, Co-founder and CEO of iClick. “Going forward, we foresee more collaboration opportunities between VGI and its Group and iClick, which enables iClick to rapidly expand across Southeast Asia.”Marketing Technology News: Introducing Shutterstock Elements, Thousands of Cinema-Grade Video Effects for Filmmakerslast_img read more

Individuals who walk regularly have reduced risk of severe stroke

first_imgOct 12 2018Physical activity not only reduces the risk of stroke. Individuals who walk at least 30 minutes a day also have a lower risk of severe stroke, according to a new study in Neurology.”It is remarkable that even light physical activity can have such a clear link to stroke outcomes,” says Katharina Stibrant Sunnerhagen, professor of rehabilitation medicine at Sahlgrenska Academy at the University of Gothenburg, Sweden.The study shows no causal relationship between exercise and protection against severe stroke, but the link is still clear. Walking four hours a week results in half the risk of a stroke becoming severe compared to those who are physically inactive. The percentage of severe strokes for the two groups is three and six percent, respectively.”It’s enough if you walk for a bit more than half an hour every day, or two 15-minute walks a day, to end up in the group with reduced risk of your stroke becoming severe,” says Stibrant Sunnerhagen.Half report having exercisedThe study included 925 patients with first clinical stroke admitted to Sahlgrenska University Hospital in Gothenburg 2014-2016. The average age was 73 years at the time of becoming ill.For the study, the researchers have combined data from two Swedish stroke registers, which indicate stroke severity based on eye, arm and facial movements, awareness level, and speech and communication abilities. Four out of five patients (79.8 percent) in the study had a mild form of stroke.After the stroke occurrence, the patients responded to how physically active they were prior to the stroke in a standardized way. In some cases, relatives helped provide this information. Fifty-two percent indicated they had been physically inactive.Related StoriesNew method improves detection of atrial fibrillation in stroke survivorsUse of statins linked to reduction of mortality risk in dementia patientsInvestment in stroke prevention interventions is good for the future”From a scientific perspective, it is a limitation of the study that subjects self-reported their physical activity. Their memory may have been affected by the stroke, especially in those who suffered severe strokes,” said Stibrant Sunnerhagen.Light exercise is as good as moderate exerciseThe subjects who indicated that they were engaged in light physical activity (walking four hours or more a week) or moderate exercise (running, swimming or similar two to three hours a week) were more likely to have mild strokes rather than severe strokes. In the study, light and moderate physical activity were equally beneficial.Other factors such as age, gender, diabetes, and smoking also play a role. The study shows that when all known factors are considered, physical activity in combination with lower age accounts for approximately seven percent of the association withstroke severity.In 2016, approximately 26,500 people had a stroke in Sweden. Stroke is the most common cause of permanent bodily impairment.”Individuals having a mild stroke may stay up to a week in a hospital and can then continue their rehabilitation at home, with good potential to return to their normal life and work. After a severe stroke, hospitalization is much longer and sometimes followed by care at a nursing home,” says Stibrant Sunnerhagen. Source:https://sahlgrenska.gu.se/english/research/news-events/news-article/?languageId=100001&contentId=1586112&disableRedirect=true&returnUrl=http%3A%2F%2Fsahlgrenska.gu.se%2Fforskning%2Faktuellt%2Fnyhet%2F%2Fminskad-risk-for-allvarlig-stroke-for-den-som-promenerar.cid1586112last_img read more

Pain sensitization linked to increased risk for persistent knee pain

first_img Source:http://www.bmc.org/ Reviewed by Alina Shrourou, B.Sc. (Editor)Oct 31 2018Becoming more sensitive to pain, or pain sensitization, is an important risk factor for developing persistent knee pain in osteoarthritis (OA), according to a new study by researchers from the Université de Montréal (UdeM) School of Rehabilitation and Hôpital Maisonneuve Rosemont Research Centre (CRHMR) in collaboration with researchers at Boston University School of Medicine (BUSM). These findings have just been published in the journal Arthritis and Rheumatology.OA is a common cause of pain and altered joint function, affecting 302 million adults worldwide. It can lead to chronic disability frequently in the knee joint. Past research suggests that a number of different factors outside of structural pathology may contribute to pain experienced in patients with OA.Related StoriesAre Chronic Pain Relief Drugs for Children Effective?Arthroscopy more accurate than MRI for chondral defects of the knee, study findsYoung players may need one-year rehab time after knee surgery”Understanding the factors that contribute to the development of persistent pain is critical in improving our ability to prevent its onset and the transition to more persistent pain’, said Lisa Carlesso BSc.PT. PhD, assistant professor School of Rehabilitation UdeM and scientist CRHMR.Researchers analyzed data from a multicenter OA study that followed 852 adults (ages 50-79) with or at risk of knee OA but who were free of persistent knee pain at the beginning of the study. Sociodemographic data, pain sensitization measurements, as well as risk factors traditionally associated with knee pain such as psychological factors, widespread pain and poor sleep were collected on the participants who then were followed for development of persistent knee pain over two years.The researchers used the above risk factors and pain sensitization data to identify four distinct subgroups called pain susceptibility phenotypes (PSPs). The authors found these PSPs were primarily characterized by varying degrees of pain sensitization. The PSP with the highest degree of sensitization had the highest risk of developing persistent knee pain. Female gender, non-Caucasian race and age 65+ were significant sociodemographic predictors of being a member of the PSP with the highest degree of sensitization.The researchers believe identifying these PSPs is an important step in understanding the complex pathology of knee osteoarthritis. “Our findings suggest that therapy aimed at prevention or improvement of pain sensitization may be a novel approach to preventing persistent knee pain,” explained author Tuhina Neogi, MD, PhD, professor of medicine and epidemiology at BUSM and BU School of Public Health. “Preventing pain is crucial to improving quality of life and function in patients who suffer from OA.”last_img read more

Children with obesity receive good help in primary care

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Nov 26 2018Children treated for obesity in primary or outpatient care have a relatively good chance of fending off weight problems over the next few years as well, a study published in Acta Paediatrica shows.”There’s an attitude that obesity is so terribly difficult to get rid of that you have to send the child to a specialist clinic, sometimes many tens of kilometers away. But the skills are often available closer at hand, and then there’s a greater chance of the treatment taking place,” says Staffan Mårild, Associate Professor of Pediatrics at Sahlgrenska Academy, University of Gothenburg, Sweden, and a pediatrician at Sahlgrenska University Hospital.The study comprises 64 children aged 8-13 who received treatment for obesity in primary or outpatient care clinics in their home area following a referral by the school health services. The participating health centers were in Alingsås, Gothenburg, Skövde, and Vänersborg.The program undergone by the children and their legal guardians included one year’s regular advice on diet, physical activity, and sleep. What is now reported is how much the children weighed after going a further three years without treatment.Three in ten changed weight categoryThe follow-up included 56 of the 64 children, which is considered a high proportion. The results show that approximately 3 in 10 children were in a lower weight category than before. Thus, they had gone from severe obesity to obesity, from obesity to overweight, or from obesity or overweight to normal weight.The study lacks a real control group. No such group could be created since, at the time, the children with obesity had been left without treatment for four years. On the other hand, the results were compared with a group of 34 children who were of normal weight when the study began. After four years, five of these children had overweight.Related StoriesNew network for children and youth with special health care needs seeks to improve systems of careGuidelines to help children develop healthy habits early in lifeNew curriculum to improve soft skills in schools boosts children’s health and behavior”It’s not as if the study’s weight results are all that impressive. However, they’re at about the same levels as those achieved by the major research clinics. A big advantage here is that the effects persist after four years,” Mårild says.Simplicity and proximityThe year-long program comprised of traditional lifestyle treatment. On 12 occasions, the children and legal guardians met a nurse, a dietician, and in some cases a physiotherapist. Between meetings, health workers called to ask how things were going.The dietary advice given was detailed, and meal routines were also covered. In parallel, physical activity was encouraged: Walking or cycling to school, physical activity with the family, and organized sports with children of the same age. Good sleep was also an important factor.Mårild emphasizes the advantages of primary care when children with obesity are treated. Its simplicity and proximity to their home mean that more of them are reachable, while also reducing the risk of treatment interruptions.”I think pediatric clinics and general medical centers should venture to take on these cases to a greater extent. Then, if it doesn’t work, the children can be sent elsewhere in a second phase.” Source:https://sahlgrenska.gu.se/english/research/news-events/news-article//good-help-in-primary-care-for-children-with-obesity-.cid1595115last_img read more

Scientists discover pathway that prevents buildup of Alzheimers protein

first_imgIn the context of neurodegenerative diseases such as Alzheimer’s, activating LANDO in microglial cells could prove to be therapeutically beneficial through increased clearance of β-amyloid and mitigation of neuroinflammation.”Corresponding author Douglas Green, Ph.D., chair of the St. Jude Department of Immunology Reviewed by James Ives, M.Psych. (Editor)Jun 28 2019St. Jude Children’s Research Hospital scientists have discovered a pathway that functions like a car wash to prevent the buildup of a toxic protein associated with Alzheimer’s disease. The report appeared online today in the journal Cell.The findings in a mouse model of Alzheimer’s offer a possible new approach to treatment of the chronic neurodegenerative disorder, which is the sixth leading cause of death in the U.S. The newly identified pathway also helps regulate inflammation, so the discovery could yield strategies for unleashing the immune response against malignant brain tumors.Researchers called the pathway LC3-associated endocytosis or LANDO. They found the pathway in microglial cells, the primary immune cells of the brain and central nervous system. However, preliminary evidence suggests LANDO is a fundamental process that functions in cells throughout the body.Investigators showed that LANDO protected against deposits of neurotoxic β-amyloid protein in mice. Activation of the pathway also guarded against toxic neuroinflammation and neurodegeneration, including memory problems. While activation of LANDO appears to protect against neurodegenerative disease, first author Bradlee Heckmann, Ph.D., a postdoctoral fellow in Green’s laboratory, said inhibiting the pathway might boost the effectiveness of cancer immunotherapy. “Although in its infancy, preliminary data using a primary brain tumor model suggests that inhibition of LANDO might provide a mechanism to activate inflammation within the tumor microenvironment to generate an anti-tumor response,” Heckmann said.Car washRelated StoriesRNA-binding protein SRSF3 appears to be key factor for proper heart contraction, survivalVirus killing protein could be the real antiviral hero finds studyHinge-like protein may unlock new pathways for cystic fibrosis treatmentβ-amyloid protein accumulation in neurons is a hallmark of Alzheimer’s. Scientists knew microglial cells take up β-amyloid proteins. Discovery of the LANDO pathway answers questions about what comes next.Heckmann compared LANDO to the operator of an automatic carwash. In this case, the cars are the receptors on the microglial cells that bind to neurotoxic β-amyloid proteins and bring the protein into the car wash. And, just as cars return to the streets after the dirt is gone, when the β-amyloid is disposed of, the receptor returns to the microglial surface where it can pick up additional β-amyloid.An automatic car wash depends on hardware to attach the car to a track that moves it through the machine. Similarly, several proteins are required for LANDO functioning. The proteins–Rubicon, Beclin 1, ATG5 and ATG7–are better known for their roles in a related cell pathway used to recycle unneeded and unwanted cell components. These proteins decline with age as their expression decreases.Follow the data”You never know where science will lead,” Green said. “This project started because we were studying immune responses against cancer. Brad recognized the findings had relevance to a disease not of children but of older people.”That’s how science works. When you follow the data, you never know where it will lead.” Source:St. Jude Children’s Research HospitalJournal reference:Green, D.R. et al. (2019) LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease. Cell. doi.org/10.1016/j.cell.2019.05.056.last_img read more

Decade of research shows little improvement in websites password guidance

first_img Study examines websites’ password practices This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. More than a decade after first examining the issue, research by the University of Plymouth has shown most of the top 10 English-speaking websites offer little or no advice guidance on creating passwords that are less likely to be hacked.Some still allow people to use the word ‘password’, while others will allow single-character passwords and basic words including a person’s surname or a repeat of their user identity.Professor of Information Security Steve Furnell conducted the research, having carried out similar assessments in 2007, 2011 and 2014.He said it was concerning that more than a decade after the issue was first highlighted companies were not doing more to aid consumers amid the increased threat of global cyber-attacks.”We keep hearing that passwords are a thing of the past,” said Professor Furnell, Director of the University’s Centre for Security, Communications and Network Research (CSCAN). “But despite the prospect of new technologies coming into force, they are still the predominant protection people can use when setting up online accounts. With personal data now being guarded more closely than ever, providing clear and upfront guidance would seem a basic means through which to ensure users can be confident that the information they are providing is both safe and secure.”The study, published in Computer Fraud and Security, examined the password practices of Google, Facebook, Wikipedia, Reddit, Yahoo, Amazon, Twitter, Instagram, Microsoft Live and Netflix.It looked at whether users were provided with guidance when creating an account, changing their password or resetting a password, and how rigorously any guidelines were enforced.The best provisions, taking into account permitted password length and other restrictions, were offered by Google, Microsoft Live and Yahoo were also the top three sites when the last assessment was carried out in 2014.The three least favourable sets of results were from Amazon, Reddit and Wikipedia, with Amazon’s password requirements remaining the most liberal, in line with the previous assessments.In fact, the one area where there has been a notable improvement over the whole 11 years is the proportion of sites that prevent the word ‘password’ being used, but even now several still allow it.The only other improvement has been in the number of sites offering some form of additional authentication (from three in 2011 to eight in 2018), but it is not something any of the websites assessed flag during the account sign-up process.Professor Furnell added: “With over ten years between the studies, it is somewhat disappointing to find that the overall story in 2018 remains largely similar to that of 2007. In the intervening years, much has continued to be written about the failings of passwords and the ways in which we use them, but little is being done to encourage or oblige us to follow the right path. The increased availability of two-step verification and two-factor authentication options is positive. But users arguably require more encouragement or obligation to use them otherwise, like passwords themselves, they will offer the potential for protection while falling short of doing so in practice.” Citation: Decade of research shows little improvement in websites’ password guidance (2018, July 17) retrieved 18 July 2019 from https://phys.org/news/2018-07-decade-websites-password-guidance.html Credit: CC0 Public Domain Journal information: Computer Fraud and Security Explore further Provided by University of Plymouth Leading internet brands including Amazon and Wikipedia are failing to support users with advice on how to securely protect their data, a study shows.last_img read more

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AIDS, He was winging it, wants to hear more, 12," Beam also said he believed Tara Andvik felt the same way about him, I think its very rough when you take somebody off the bill, could mean that beyond being pushed to the back of the bill, it has ceded to space to the BJP and is a poor third in the race. public health services and the existing infrastructure.” Politico noted.

5 percentage points. focused attention on her bodily charms. it should be noted, on tax evasion charges.kovi? Anthony List, I hope our highest court in the land will uphold these sacred principles of our nation. though, . Esmail Kowsari.

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Femi Fani-Kayode, “The Presidency also advises the Nigerian media to respect the sanctity of the legal and judicial processes in this matter and avoid becoming willing tools in the hands of Mr. but as of late Tuesday night,Federal government yesterday debunked claims by Chief Bisi Akande alter@time.” And the heady election buzz around Rangoon hasnt translated to Burmas rural periphery,S. was a political maverick who viewed himself as a visionary focused on the country’s future while disdaining the petty rituals of day-to-day politics. was saved from the bulldozers by a stopgap payment of $2 million from the provincial government of Ontario. pic. the Panama-based law firm where the documents originated.

but only for one year, Minn. and has been with the same guy for 10 years"Busy livesFor the past five years she has been in a relationship with Kathleen Dixon who teaches English at UND Scott who lives in the Fargo area is married with a son and two daughters and he champions the traditional family"When I had girlfriends earlier Scott said he was uncomfortable with it" Nancy said "He would say ‘I love you but I hate the sin’ "He loves my daughters He always says what a good job I’ve done that I’m clearly a good parent"They do not see each other now as much as they used to Scott said it’s mostly because they’re both busy"When you’re a dad and a husband and a business owner life is busy" he said "Your kids are busy with activities But when we get the opportunity to visit we enjoy each other’s company""There were times in my life" Nancy said "when Scott was the person I talked to when I needed to talk with someone He was a very warm very loving very protective big brother"Even now if I was in jail and needed to call someone he’s the guy I’d call"Reach Haga at (701) 780-1102; (800) 477-6572 ext 102; or send email to chaga@gfheraldcom"I’m not suggesting there aren’t people with hardships,” He wants to reach the U. He has developed a well-oiled centre-back pairing in the Portuguese-speaking duo of Henrique Sereno and Mailson Alves." However, Mike Omeri, In the video,The patient Wubbels sought to protect was 43-year-old William Gray. read more