Tag: 娱乐地图

October 11 2013We received these wonderful photos

first_imgOctober 11, 2013We received these wonderful photos from architect Jim Horecka, who has visited Arcosanti many times over the years. Thank you so much, Jim![Photo credit for all of the photos in this report: 2013 James Horecka, AIA, Architect]On the last day of the Paolo Soleri Memorial Cosanti  and Arcosanti alumni, and friends supportive of Paolo Soleri’s efforts, gathered at the Paolo Soleri Scottsdale Bridge and Plaza.[photo: Paul from Flam Chen waiting with a large lense for the exact Solar Noon].Text of Jeff Steins speech at the Soleri Bridge on Sunday, September 22. 2013.“Thank you Donna Isaac, Mayor Jim Lane, and welcome.Thank you all for being here on a beautiful Sunday in Scottsdale, Arizona, home for 66 years to the architect, philosopher, writer, lecturer, EXPLORER – and our neighbor –  the late Paolo Soleri. We are gathered today at his Soleri Bridge and plaza to celebrate Paolo. We are here at this public place, designed by an individual, funded by a government – the city of Scottsdale – for the enjoyment of its citizens. We are those citizens.This bridge represents decades of thought and the ideals of its architect Paolo Soleri; his wish to connect us in this desert city to the sun and seasons, to earth and it’s ecology, his wish to use architecture to help connect us all to each other. That wish to define new relations and ways to celebrate them continues in this place today.The GREAT WORK of our generation: the transformative and radical effort to change human-Earth relations from disruptive and destructive to naturally enhancing and beneficial was first modeled for us by Paolo Soleri. His legacy of writing, of building, of BRIDGE-building, really, is what we celebrate today.[photos are of the FLAM CHEN performance during the event].A bridge is a way to cross over, a way to make a transition to the other side of something.  A bridge marks the end of one thing, the beginning of another. At this bridging moment in the history of our culture, we hope our presence here today will serve as a bridge for us to continue the work Paolo Soleri began to make a transition to a better, a more coherent way to be, on the land, in the world.The writer E.B.White  said, “I arise in the morning torn between a desire to save the world and a desire to savor the world. This makes it hard to plan the day.” Paolo Soleri had this same issue. But his life’s work, at Cosanti, at the enduring urban laboratory Arcosanti, including the Soleri Bridge and the new bas relief murals at the Arcosanti Interchange on I-17, all allow us new places and new ways to do both those things at once. Paolo Soleri created ways to connect and enjoy living, human connections, he modeled ways to bring together mind and heart and hand to develop a new consciousness of how the earth works, a new framework for the practice of architecture and urban design.Paolo Soleri’s work of cultivating awareness and attention entails a commitment to tend to and take responsibility for our communities. A clearer awareness of who we are in relation to the larger whole of earth’s ecology, rooted in respect and reverence for the whole, requires of us both a response and a responsibility. Paolo Soleri, who we honor here today, who lived and created in our midst for nearly 94 years, made a real effort to leave the world a little better than he found it. And we gathered here today intend to continue to create a reasonable alternative equal to the needs of our age. This is our time, our responsibility, and I congratulate you here today for recognizing this with your presence. I urge you to go forth from this place today with a renewed spirit, a new sense of what is possible based on the life and work of Paolo Soleri.  Thank you in advance for doing it.”last_img read more

Rep Bellino announces local office hours

first_img Categories: Bellino News 09Nov Rep. Bellino announces local office hours State Rep. Joe Bellino of Monroe will host office hours on Monday, Nov. 27 to meet with residents of Monroe and Wayne counties.“Some of the best ideas are generated from the members in our community,” Rep. Bellino said. “I welcome anyone with concerns, ideas or issues to join me.”Rep. Bellino will meet with residents at the following times and locations:9 to 10 a.m. at Biggby, 26614 Telegraph Road in Flat Rock;10:30 to 11:30 a.m. at Tim Hortons, 404 S. Monroe St. in Monroe; andNoon to 1 p.m. at Carleton Branch Library, 1444 Kent St. in Carleton.Appointments are not necessary during office hours. Anyone unable to attend is encouraged to contact Rep. Bellino’s office at (517) 373-1530, email JosephBellino@house.mi.gov or visit www.RepBellino.com.last_img read more

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first_imgSponsor Advertisement I wasn’t amused that the precious metals shares got sold off as heavily as they did…Just eye-balling the Kitco gold chart below, it’s obvious to me that the gold price, despite several serious attempts to do so, wasn’t going to be allowed to break above the $1,720 spot mark anywhere on Planet Earth yesterday and, with the exception of the high tick of the day [$1,724.10 spot] at the London p.m. gold fix, it didn’t.The gold price finished the day at $1,716.00 spot…up a whole 80 cents from Friday’s New York close.  Net volume was very light at only around 108,000 contracts.Here’s the New York Spot Gold [Bid] chart on its own…and three of four of gold’s attempts to climb above the above mentioned price got turned back…and the glaring one is at the 3:00 p.m. GMT London gold fix…10:00 a.m. Eastern.Silver rallied right from the New York open on Sunday night…and its Far East high came around 10:00 a.m. Hong Kong time.  It was all down hill from there until the noon silver fix in London.That proved to be the low of the day.  The subsequent rally ran into the usual not-for-profit seller at the afternoon London gold fix…and that was it.Silver closed at $33.66 spot…up 22 cents on the day.  Net volume was a rather unexciting 30,500 contracts…give or take.The dollar index, which closed on Friday at 80.24, was under pressure right from the get-go in Far East trading on their Monday morning…which most likely explains the initial rally in gold and silver.The index sank under the 80.00 mark around 3:00 p.m. in Hong Kong…about an hour before London opened.  From there it kept declining in fits and starts…closing around the 79.89 mark…down about 35 basis points on the day.It was obvious that both gold and silver wanted to rally at midday in London…and at the Comex open…but it’s equally obvious that there were forces standing by to make sure that it didn’t happen.The US dollar index packed up on the ino.com Internet site around 9:00 a.m. yesterday morning…and as you can see, I stole the chart below from one of Peter Spina’s websites…goldseek.com…and I’m sure he won’t mind.As you are more than aware, the shares did very poorly yesterday…and the HUI finished down 2.33%.  The HUI from that yahoo.com website has been M.I.A. for many days now…and here’s one that Scott Pluschau offered up in its stead.(Click on image to enlarge)The silver shares fared little better…and despite the metal itself finishing well in the black, the shares got sold down pretty hard as well.  Nick Laird’s Silver Sentiment Index closed down 1.68%.(Click on image to enlarge)The CME’s Daily Delivery Report for ‘Day 3’ in the December delivery month showed that 1,906 gold and 712 silver contracts were posted for delivery on Wednesday within the Comex-approved depositories.In gold, the big short/issuer was Deutsche Bank with 1,741 contracts posted for delivery…and in very distant second place came the Bank of Nova Scotia with 162 contracts.  The big long/stopper in gold was JPMorgan Chase with 1,565 contracts…275 in its client account and 1,290 in its proprietary [in house] trading account.  There were about a dozen other small stoppers accounting for the rest.In silver, the big short/issuer was Deutsche Bank as well with 579 contracts…and JPMorgan, in its proprietary account, was in second with 106 contracts.  The biggest long/stopper was JPMorgan in its client account with 341 contracts.  Second was Barclays with 225 contracts…and third was Credit Suisse First Boston with 98.The Issuers and Stoppers Report is well worth a few minutes of your time…and the link is here.  Note the delivery info in palladium as well…Deutsche Bank, JPMorgan and Barclays.If you haven’t figured it out already, it should be patently obvious that JPMorgan is at the center of the precious metals universe.There were no reported changes in either GLD or SLV yesterday…and no sales report from the U.S. Mint, either.Over at the Comex-approved depositories on Friday, they reported receiving no silver at all…but shipped 458,050 troy ounces out the door.  The link to that activity is here.Washington reader S.A. had no charts for me today…but he more than made up for it by sending me a photo of the latest addition to the Oregon Zoo.Being a Tuesday column, I have a few more stories than usual for you today…and I’ll leave the final edit up to you.I have no doubt that the CFTC is publishing accurate data on COMEX silver. Without that data, I couldn’t begin to make a case for manipulation. The problem is that all the agency does is to publish accurate data that prove that silver is manipulated in price…and then refuses to react to the clear proof of manipulation. Due to a decrease in reported spread positions in this week’s disaggregated COT report, JPMorgan’s 38,000 contract silver short position “only” increased to 34.7% of the entire net COMEX short position from the previous week’s 34%. But the 190 million ounces that the 38,000 contracts represent is equal to 25% of the world’s total annual silver mine production of 760 million oz. If one trading entity was short 25% of the annual world production of any other commodity that entity would be in jail the day it became known. For that entity in silver to be a systemically important US bank is shocking in its own regard. In many ways, I admit that this is so extreme as to not be fully comprehendible. Believe me when I tell you that I can hardly comprehend that I label JPMorgan as crooked and get away with it. – Silver analyst Ted Butler… 01 December 2012Even though volume was pretty light in both silver and gold yesterday, it was obvious [at least to me] that the prices of both metals weren’t allowed to get far, even though the dollar index dropped below the psychologically important 80.00 mark.I wasn’t amused that the precious metals shares got sold off as heavily as they did…and I’ll quote a paragraph on this from my Saturday column…“I’d like to think that it’s strong hands buying all the shares that are falling off the table as weak-kneed day traders hit the ‘sell’ button…but I’m always concerned that “da boyz” are buying up all these shares in order to dump them later when they need to suppress the share prices as well.  I know that John Embry would be in total agreement with this scenario.  But maybe I’m looking for a black bear in a dark room that’s not there.”I leave it up to you, dear reader, to ponder the notion of whether or not there is any truth in that paragraph…for, or against.As you may remember, I’ve had correspondence with Scotiabank here in Canada about whether or not they were the bank that was fingered by the CFTC as the “non-U.S. bank” in their November Bank Participation Report.  All enquires sent by myself…and other readers…ended up with the same “non-denial denial” type of answer.So, on Sunday, I sent an e-mail off to the ombudsman at Scotiabank…and here is what I had to say…02 December 2012Mr. Charles DougallOmbudsmanScotiabankHi Charles,I’ve been trying to get an answer to a question that I asked of your firm a month or so ago.I started off with Andy Montano at Scotia Mocatta…and have since graduated to Rick Waugh…and got immediately passed off to Dave Shearim.  I have not received a direct answer, except for the usual ‘non-denial denial’…the normal runaround corporations give when they really don’t want to answer and are just trying to blow someone off.I’m not asking for trading secrets, or the trading positions of any client [in-house or otherwise] that may exist over at Scotia Mocatta…as I fully understand that this client privileged information.Here is the sequence e-mails as posted in ‘The Wrap’ section of my daily column over at Casey Research on November 6th…[There was a bit more to this e-mail than that at the end, but what you see above is the essence of what I sent]The reply I got back on Monday was as follows…Dear Mr. Steer, We acknowledge receipt of your email dated December 2nd. After a preliminary review of your email, we wish to inform you that there are certain issues that are deemed to be outside the mandate of the Office of the Ombudsman, which may include the issue(s) you have raised.  Having said that, we will make inquiries into your concerns and will respond to you further in due course. Yours truly, Marlaine Radke Assistant Ombudsman Scotiabank – Executive Offices 44 King Street West Toronto, ON  M5H 1H1 Telephone: (416) 933-3299 Fax:  (416) 933-3276And that’s where it sits at this point…and I’ll let you know the contents of any further correspondence that I receive, or send.  I get the impression from the tone of the reply, that I’m not going to get very far, but you never know.Both gold and silver came under selling pressure the moment that Far East trading began on their Tuesday.  Then, as you’ve already noted, the bid disappeared shortly before 2:00 p.m. Hong Kong time…or the high-frequency traders showed up…and the gold price dropped ten dollars in just a few minutes.  This decline occurred in all four precious metals.Since those lows, they have recovered somewhat…and their respective rallies have continued [in fits and starts] into the first hour or so of trading in London.  Whether these rallies will be allowed to continue is impossible to tell…but as I also said in my Saturday column, it’s a mug’s trying to predict what the precious metals will do price-wise when the heavy hands of JPMorgan Chase et al are in the market.The dollar index has been in a slow but steady decline all through Far East and the early London trading session as well…and is down about 23 basis points as I hit the ‘send’ button at 5:15 a.m. Eastern time.  Volumes are monstrous…over 45,000 contracts in gold…and 9,000+ in silver.  Fortunately, all of this…along with New York’s price/volume activity…will be in Friday’s Commitment of Traders Report, as the cut-off is at the 1:30 p.m. Eastern time Comex close today.And I suggest you re-read Ted Butler’s quote under the cartoons above to give you some idea of the meaning of “obscene and grotesque” when it come to a short position in the precious metals…especially silver.  Between JPM and Scotiabank…if they are the second big silver short…they hold a short position of over 45% of the entire Comex futures market in silver.  That was as of the Tuesday cut-off for last week’s COT Report…and it may have declined since.  But by how much, won’t be known until Friday.What the precious metals do price-wise is entirely up to them…and has nothing to do with legitimate supply and demand fundamentals.That’s more than enough for today…and I’ll be very interested in the price action in New York when I switch my computer on later this morning.See you tomorrow. Tosca Mining Corporation’s goal is to acquire advanced stage projects that can be placed into production quickly. The company’s primary asset is the Red Hills Molybdenum/Copper project located in Presidio County, Texas. A program to confirm, and expand the considerable size and potential of the project and evaluate various economic scenarios was completed in 2011. Tosca recently received results from the 13 remaining holes from its phase two, 16,000 M (4,873 m) diamond drill program. Per Tosca’s Chairman, Dr. Sadek El-Alfy, “the drill program has successfully verified historic drill results of the shallow Copper-Molybdenum cap and confirmed the presence of a deeper, well mineralized Molybdenum Porphyry deposit.” The results of 21 holes drilled through the copper/moly cap in Tosca’s 2011 drill program give a weighted average grade of 0.39 % Cu over a core length of 113 feet (34.5 m). Since the copper cap is subhorizontal, the average core length can be interpreted as being approximately equivalent to true width. The copper/moly cap is crescent shaped, approximately 4,000 feet (1220 metres) long and 400 feet (122 m) to 1000 feet (305 m) wide.The 2011 program encountered numerous thick  Molybdenum mineralized intervals including Hole TMC-25 wich  intersected 1,189 feet (362.4 m) averaging 0.089 per cent Mo including 830 feet (253 m) of 0.1 per cent Mo from 359 feet (109.8 m) to the bottom of the hole. Hole TMC-29 cut 989 feet (301.4 m) averaging 0.09 per cent Mo including 139 feet (42.4 m) of 0.16 per cent Mo. The molybdenum grades are similar and in some cases higher than those of projects currently considered of potential economic interest.”Aggressive plans are in place for 2012 to conduct metallurgical tests, produce an updated resource estimate and  Pre Economic Assesment. Tosca is operated by an experienced mine development team, operates in Texas, a  mine-friendly jurisdiction and its property iseasily accessible with infrastructure in place to advance operations. Please visit our website to learn more about the company ad request information.last_img read more

Fortyfive states and the Department of Justice ar

first_imgForty-five states and the Department of Justice are claiming that generic-drug prices are fixed and the alleged collusion may have cost U.S. business and consumers more than $1 billion.In their complaint, prosecutors say that when pharmacies asked drugmakers for their lowest price, the manufacturers would rig the bidding process.”The companies would work out in advance who would get the lowest price and then the other competitors may put in what we would call a cover bid,” says Michael Cole, who heads the antitrust department at the Connecticut attorney general’s office. (Such bids give the appearance of competitive bidding.)Through subpoenas, Cole’s team has assembled millions of texts, emails and phone calls between 2012 and 2015. The prosecutors say the records show executives divvying up customers, setting prices and giving the illusion that generic pharmaceuticals were transacted in an open and fair marketplace.Because of this price-fixing scheme, prosecutors say, health insurance premiums and copays increased. They also say tax-funded programs like Medicare and Medicaid overspent on drugs.So far, two executives from Heritage Pharmaceuticals have pleaded guilty to antitrust crimes. Both are now feeding information to prosecutors who say the two rigged prices on, among other drugs, the common antibiotic doxycycline, which shot the price up 8,000 percent.”To the extent that taxpayers have had to pay that bill, I think that the taxpayers should recover. And we will get involved on the civil side and recover damages for the U.S. government,” Makan Delrahim, head of the Department of Justice’s antitrust division, said at a seminar.The fact that the Department of Justice is involved has caught the attention of class-action lawyers.Jason Dubner, an attorney for Butler, Rubin, Saltarelli & Boyd, says the allegations are so massive that prices throughout the generic industry could have been affected. “You start to get an understanding just how widespread this alleged conspiracy was to cover so many different types of cures,” he says.Law firms that specialize in class actions have already lined up as many as 80 companies that may have paid too much, including retail pharmacies, employee unions and insurance companies. Dubner predicts more will join as the lawsuit progresses, perhaps even individual consumers.The pharmaceutical manufacturers named in the complaint have either declined to comment or denied the allegations, saying they have a robust compliance program.Ronny Gal, a market analyst for Sanford Bernstein, says on average, the generic-drug industry has lowered prices for consumers. But, he says, in an efficient marketplace, generic-drug wholesalers should have kept prices in check.”In a market that has only three or four really large distribution organizations, they are sometimes tempted to maximize their own profits in a way that does not always 100 percent reflect the best interest of their clients,” Gal says.This is what investigators are looking at now. In their complaint they suggest — but don’t allege — that the price-fixing conspiracy also involved drug distributors. Prosecutors are sending more subpoenas and planning a new complaint.”It could be more generic manufacturers, it could be more drugs, it could be more entities in the distribution chain. It could be all of that,” Cole, of the Connecticut attorney general’s office, says.A spokesperson for McKesson, one of the largest generics distributors, said the company is cooperating with requests for information from prosecutors and that it competes aggressively for the lowest price available.Based on what’s in the current lawsuit, Gal estimates an eventual settlement would be around $1 billion. But he says that number could go as high as $5 billion, especially if more drugs are included. Copyright 2018 WSHU. To see more, visit WSHU.last_img read more

A major medical association today suggested that d

first_imgA major medical association today suggested that doctors who treat people with Type 2 diabetes can set less aggressive blood sugar targets. But medical groups that specialize in diabetes sharply disagree.Half a dozen medical groups have looked carefully at the best treatment guidelines for the 29 million Americans who have Type 2 diabetes and have come up with somewhat differing guidelines.The American College of Physicians has reviewed those guidelines to provide its own recommendations, published in the Annals of Internal Medicine. It has decided that less stringent goals are appropriate for the key blood sugar test, called the A1C.”There are harms associated with overzealous treatment or inappropriate treatment focused on A1C targets,” says Dr. Jack Ende, president of the ACP. “And for that reason, this is not the kind of situation where the college could just sit back and ignore things.”The ACP, which represents internists, recommends that doctors aim for an A1C in the range of 7 to 8 percent, not the lower levels that other groups recommend.For people who have already achieved a lower level, “consider de-intensifying treatment,” Ende says. “That is, reducing one of the medications, stopping a medication, just allow the A1C to be between 7 and 8.”Some studies have shown that people who have aggressively pushed to lower their blood sugar are at somewhat higher risk of premature death. People also suffer from low blood sugar as a result of aggressive treatment.That was the case for Valerie Pennington, a special-needs teacher who lives in Odessa, Mo. She was diagnosed in her mid-40s and put on an aggressive treatment regime.”The nurse at school — because I was going low so much — made me get an alarm clock.” Otherwise, she says, she didn’t realize when she was about to faint. “At one point, one of the children actually had to save me because I had just zoned out.”Pennington also had trouble losing weight because one of the drugs she took for diabetes often leads to weight gain.The upside for her — and it’s a big one — is that once she was off that drug, she shed 100 pounds and has been able to keep her blood sugar in the normal range.She says her general-practice doctor wasn’t fixated on a particular number for her A1C, “but my ophthalmologist would always check the number because above 6.5 the chances of getting retinopathy grow.”People with elevated blood sugar risk more than their vision, says Dr. George Grunberger, who was on the committee that drew up diabetes guidelines for the American College of Endocrinologists and is past president of the American Association of Endocrinologists.”The moment your glucose goes above normal, it’s incurring damage to the back of the eye, to kidneys and to nerves, especially in your feet,” he says.Grunberger says he is stunned to see the American College of Physicians giving more weight to the risks of low blood sugar than the benefits of keeping it under control.”My concern is this will be a message to many practicing physicians saying, ‘Well, don’t worry about it so much, because it’s OK,’ ” he says.He is even more surprised by the suggestion to let a patient’s blood sugar levels rise if the A1C is below 7 percent. He says that is based on a misinterpretation of old studies conducted for purposes other than setting optimal blood sugar levels.The American Diabetes Association also rejects the ACP’s recommendation.”We stand by our guidelines,” says Dr. William Cefalu, chief scientific, medical and mission officer of the ADA.Cefalu says, for one thing, the new guidance gives short shrift to a new generation of drugs that are in use to control blood sugar, “and these drugs do have less risk for hypoglycemia [low blood sugar] and some have very favorable effects on body weight and other cardiovascular risk factors.”Everyone does agree on one thing: There is no one-size-fits-all solution.”These are recommendations,” Ende, the ACP president, says. “Your doctor should make a decision based upon his best information or her best information as well as your particular case.” Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

Its been 40 years since doctors in San Antonio fi

first_imgIt’s been 40 years since doctors in San Antonio first organized a conference about breast cancer to educate local physicians. A few nationally known experts flew in, and at an airport hotel, some 140 people — mainly men — talked over slide presentations. The event has grown — and evolved — since 1978. This year, some 7,500 people gathered in early December at the San Antonio Breast Cancer Symposium, the world’s largest annual conference devoted to breast cancer. Another thing that makes the symposium special is the presence of a couple of hundred patient advocates alongside scientists and clinicians. In San Antonio, advocates stand up and ask questions after plenary talks. Patients sit on panels, contribute papers and weigh in on research prioritiesBy speaking up, advocates at the meeting have shifted the direction of breast cancer research. Some are alive, improbably, as a consequence of new treatments enabled and promoted by their advocacy. In recent years, advocates have steered attention toward metastatic disease.When I practiced oncology years ago, there was little concept of cancer-patient activism, apart from fundraising and helping spread official, doctor-approved recommendations. Since my personal breast cancer diagnosis, 16 years ago, cancer advocacy has changed dramatically.For patient advocates, now including me, visiting San Antonio has become a December ritual. We learn what’s happening in the field, network and see old friends. We hug and stroll the River Walk. We cry, remembering acquaintances who’ve died.For a growing number of patients living with metastatic breast cancer, learning has become a priority. As more clinical trials and new options for testing and treatment are becoming available, patients are educating themselves in the hope of saving themselves. And they are voicing their needs.The San Antonio symposium was one of the first medical conferences to include patient advocates. However, members of the local Alamo Breast Cancer Foundation recall the days when they weren’t invited to the sessions. Sandi Sanford, 74, runs the advocacy program for the group, which she joined in 1994. “I was six months out from surgery and still had a couple of chemotherapy treatments to go,” she told me. In 1996, she and other “Alamo” women staffed an information booth during the symposium, then held in a downtown Marriott ballroom. “There was no program for us,” Sanford told me. “We’d sneak into the sessions, stand in the back of the room and lean against the wall.”In 1998, the Alamo Breast Cancer Foundation started a grants program for advocates to help them travel to the San Antonio meeting; it expanded. Money for the Alamo educational programs comes mainly from industry. The annual budget, over $250,000, mostly goes toward room rental and convention center facility fees, video support for social media and livestreaming, Sanford told me. “These funds are used for educating advocates in an unrestricted manner,” she said. “We are not allowed to play favorites and we don’t promote any company’s drug.”Doctors attending the symposium value the patients’ participation. “There is a very clear and prominent role for patient advocates here at the meeting,” said Dr. Nikhil Wagle, a Harvard oncologist who leads the Metastatic Breast Cancer Project. At this year’s symposium, he gave a plenary talk on the genomic landscape of breast cancer. “Over the last several years, I’ve seen advocacy increase in a very positive way,” Wagle told me. “Knowing that there are patients and advocates in the room makes presenters aware of their concerns; it affects what we say and what research we do.”Speakers don’t dumb down the educational sessions for advocates. Far from it! On Wednesday evening of this year’s symposium, I stopped by a “Hot Topic” session, where experts review the days’ scientific reports. Dr. Julie Gralow of Seattle was expounding in detail on atezolizumab, a PD-L1 antibody, before a room of engaged advocates. Later, they lined up at microphones and asked detailed questions about gene mutations, fibroblasts in breast tissue and contradictory clinical trial results. Like doctors, patient advocates don’t always agree. In a lunchtime session with members of the Food and Drug Administration’s Oncology Center of Excellence, advocates raised concerns about the agency’s approval of drugs that don’t necessarily prolong survival. Some asked about the design of clinical trials. The agency’s breast cancer team, led by Dr. Tatiana Prowell, emphasized that the FDA wants to hear from patients with varied perspectives.A personal highlight of the conference — because the benefits of patient advocacy were evident — was the annual Metastatic Breast Cancer Alliance dinner held at the historic Menger hotel, steps from the Alamo.”If you went to the San Antonio Symposium in 2011, researchers had very little to say that was relevant to advanced breast cancer,” said Shirley Mertz, a former high school principal in Illinois who has been living with metastatic breast cancer since 2003. Metastatic breast cancer is an incurable condition that still carries a dim prognosis. “If you heard anything about metastatic cancer, it was on Saturday, after [most] people went home,” said Mertz, a co-founder of the alliance in 2013. Then, she added with pride, now “the program is full of metastatic breast cancer!” Dr. Elaine Schattner is a journalist, patient advocate and physician who lives in New York City. She is writing a book about public attitudes toward cancer. Copyright 2018 NPR. To see more, visit https://www.npr.org.last_img read more

This Woman Just Made NFL History

first_imgLeadership Image credit: Al Bello | Getty Images Add to Queue 2 min read –shares Staff Writer. Covers leadership, media, technology and culture. This Woman Just Made NFL History Nina Zipkin This Sunday, during the matchup between the New England Patriots and the Los Angeles Chargers, NFL referee Sarah Thomas became the first woman to be an on-field official at an NFL playoff game. It wasn’t the first time that Thomas made football history.In 2015, she became the first female official hired by the NFL, and before her hiring in 2011, she was the first female official to work in a Big Ten stadium. In 2009, she was the first woman to officiate a college football bowl game, and in 2007, she was the first woman to work at a major college football game.Before her career as a football official, Thomas, a Mississippi native and married mom of three, was a college basketball star at the University of Mobile.Related: 4 Branding Lessons From Nike’s Colin Kaepernick AdAt the start of her NFL career, she shared with CBS News how her tenure as a scholar-athlete informed her career.”Maybe at times when they made a controversial call that I didn’t think was right, I voiced my opinion, but I think they would get just as aggravated with me at times, too,” Thomas told CBS. “When I started in football officiating, I had no idea the pride and the amount of time that they put into trying to get the game right.”On social media, Jennifer Welter, the NFL’s first female assistant coach, congratulated Thomas.Today my good friend Sarah Thomas will #kickglass and become the first woman to officiate a playoff game #football #footballfamily #womeninsports #grrridirongirls #legends @ San… https://t.co/8A93bSwLUt— Dr. Jen Welter (@jwelter47) January 13, 2019center_img Learn how to successfully navigate family business dynamics and build businesses that excel. Next Article January 14, 2019 Entrepreneur Staff Sarah Thomas became the first woman to be an on-field official at a playoff game. Free Webinar | July 31: Secrets to Running a Successful Family Business Register Now »last_img read more

Individuals who walk regularly have reduced risk of severe stroke

first_imgOct 12 2018Physical activity not only reduces the risk of stroke. Individuals who walk at least 30 minutes a day also have a lower risk of severe stroke, according to a new study in Neurology.”It is remarkable that even light physical activity can have such a clear link to stroke outcomes,” says Katharina Stibrant Sunnerhagen, professor of rehabilitation medicine at Sahlgrenska Academy at the University of Gothenburg, Sweden.The study shows no causal relationship between exercise and protection against severe stroke, but the link is still clear. Walking four hours a week results in half the risk of a stroke becoming severe compared to those who are physically inactive. The percentage of severe strokes for the two groups is three and six percent, respectively.”It’s enough if you walk for a bit more than half an hour every day, or two 15-minute walks a day, to end up in the group with reduced risk of your stroke becoming severe,” says Stibrant Sunnerhagen.Half report having exercisedThe study included 925 patients with first clinical stroke admitted to Sahlgrenska University Hospital in Gothenburg 2014-2016. The average age was 73 years at the time of becoming ill.For the study, the researchers have combined data from two Swedish stroke registers, which indicate stroke severity based on eye, arm and facial movements, awareness level, and speech and communication abilities. Four out of five patients (79.8 percent) in the study had a mild form of stroke.After the stroke occurrence, the patients responded to how physically active they were prior to the stroke in a standardized way. In some cases, relatives helped provide this information. Fifty-two percent indicated they had been physically inactive.Related StoriesNew method improves detection of atrial fibrillation in stroke survivorsUse of statins linked to reduction of mortality risk in dementia patientsInvestment in stroke prevention interventions is good for the future”From a scientific perspective, it is a limitation of the study that subjects self-reported their physical activity. Their memory may have been affected by the stroke, especially in those who suffered severe strokes,” said Stibrant Sunnerhagen.Light exercise is as good as moderate exerciseThe subjects who indicated that they were engaged in light physical activity (walking four hours or more a week) or moderate exercise (running, swimming or similar two to three hours a week) were more likely to have mild strokes rather than severe strokes. In the study, light and moderate physical activity were equally beneficial.Other factors such as age, gender, diabetes, and smoking also play a role. The study shows that when all known factors are considered, physical activity in combination with lower age accounts for approximately seven percent of the association withstroke severity.In 2016, approximately 26,500 people had a stroke in Sweden. Stroke is the most common cause of permanent bodily impairment.”Individuals having a mild stroke may stay up to a week in a hospital and can then continue their rehabilitation at home, with good potential to return to their normal life and work. After a severe stroke, hospitalization is much longer and sometimes followed by care at a nursing home,” says Stibrant Sunnerhagen. Source:https://sahlgrenska.gu.se/english/research/news-events/news-article/?languageId=100001&contentId=1586112&disableRedirect=true&returnUrl=http%3A%2F%2Fsahlgrenska.gu.se%2Fforskning%2Faktuellt%2Fnyhet%2F%2Fminskad-risk-for-allvarlig-stroke-for-den-som-promenerar.cid1586112last_img read more

Nissan crisis deepens as charges loom over Ghosn case

first_imgRenault owns 43 percent of Nissan while in turn the Japanese firm has a 15-percent stake in Renault.Nissan has become the alliance’s key player however, posting sales of 12 trillion yen ($106 billion) last year compared with Renault’s 59 billion euros ($67 billion).According to the Financial Times, Ghosn was working on a merger of the two carmakers that Nissan opposed because it feared the Japanese company could be relegated to a secondary role.Jeff Kingston, director of Asian Studies at Temple University Japan, told AFP that Ghosn was “a victim of his own hubris and success.””He trampled on Japanese cultural norms with his flamboyant glory-hogging ways, and his massive compensation incited jealousies and invited retaliation,” he told AFP.’Greedy’Local media reported that Nissan’s representative director Greg Kelly, who was arrested along with Ghosn, ordered other executives to “hide salaries.”Some compensation due to other executives reportedly ended up going to Ghosn, although it is not clear how the scheme worked. Carlos Ghosn was probably the best-known foreign CEO in Japan Nissan chief Ghosn arrested over financial misconduct: reports Explore further Ghosn in happier days This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Public broadcaster NHK reported that Nissan had paid “huge sums” to provide Ghosn with luxury homes in Rio de Janeiro, Beirut, Paris and Amsterdam “without any legitimate business reason.”Even when his reputation was sky-high, he attracted criticism for a flashy lifestyle at odds with traditional Japanese corporate culture and his salary—an estimated 13 million euros in total last year.Media reports also spoke of a lavish Marie Antoinette-themed party in 2016 for Ghosn’s second wedding, at the grandiose palace of Versailles.The Yomiuri Shimbun on Tuesday quoted Nissan executives slamming Ghosn as “greedy”.”He says the right things, but in the end it’s all about money,” the daily quoted an unnamed senior employee as saying.His arrest has also raised alarms among Renault’s French workers about what lies ahead.”What worries us is the alliance with Nissan,” said Ghislaine, a production line worker at the Flins plant outside Paris—where Nissan’s popular Micra hatchback accounts for half its output. “I hope our future isn’t at risk.” Comparison of key statistics for Renault and Nissan (2017 figures) Citation: Nissan crisis deepens as ‘charges loom’ over Ghosn case (2018, November 21) retrieved 17 July 2019 from https://phys.org/news/2018-11-nissan-crisis-deepens-loom-ghosn.html Paris and Tokyo have been scrambling to contain the fall-out from the arrest, with the finance ministers of both countries declaring strong support for “one of the greatest symbols of Franco-Japanese industrial cooperation.”The scandal—the latest in a string to affect Japan Inc.—wiped millions off the stock value of all three companies but Nissan bounced back marginally in opening Tokyo trade, climbing more than half a percentage point in a falling market. ‘Flamboyant glory-hogging ways’Ghosn was once the darling of corporate and even popular Japan—even having a manga comic inspired by him—and has been the glue holding the auto tie-up together since 1999.”Ghosn is likely the most successful foreign chairman in Japan,” said Kosuke Sato, a senior economist at the Japan Research Institute.”What he did was unprecedented in Japanese corporate history.”He had a reputation as a workaholic and won the nickname “Le Cost Cutter” in France for his slash-and-burn approach to corporate restructuring.Under his stewardship, Nissan and Renault became deeply entwined. The crisis at Nissan appeared to be deepening day by day © 2018 AFP Monday’s arrest of the millionaire auto tycoon, who is credited with turning around the Nissan-Renault-Mitsubishi Motors alliance, sent shockwaves through the global car sector and corporate Japan.The Asahi Shimbun daily said Wednesday that Tokyo prosecutors believe Nissan also has a case to answer in the under-reporting of Ghosn’s package by about five billion yen ($44.5 million) over four years. Both Nissan and authorities declined to comment on the report.Nissan’s board will decide on Thursday whether to remove the 64-year-old tycoon as chairman, a staggering reversal of fortune for the Brazil-born businessman credited with creating the three-way alliance which together sells more cars worldwide than any other automaker.Ghosn’s fate appears all but sealed after his hand-picked replacement as CEO, Hiroto Saikawa, launched an astonishing broadside at his mentor, saying “too much authority” had been placed in his hands and lamenting the “dark side of the Ghosn era.”He pointedly refused to offer the deep “apology bow” that usually accompanies corporate scandals in Japan and played down the role Ghosn had personally played in reviving the firm’s fortunes.However, in France, Renault said it was sticking with the fallen manager as chief executive although it named chief operating officer Thierry Bollore as deputy CEO, handing him the “same powers” as the “temporarily incapacitated” Ghosn.After an emergency board meeting, Renault urged its sister company Nissan to share “evidence seemingly gathered” against Ghosn from a months-long internal investigation, saying it was unable to comment on the charges without this information. The crisis at Nissan deepened Wednesday as it emerged the Japanese car giant could itself face charges over the alleged financial misconduct that led to the stunning arrest of its chairman Carlos Ghosn.last_img read more

Focus will be on unemployment job creation Rahul

first_imgRahul Gandhi SHARE SHARE EMAIL Congress President Rahul Gandhi and TNCC president KS Alagiri, at a press conference in Chennai on Wednesday   –  Bijoy Ghosh Indian National Congress Published on March 13, 2019 state politics Prime Minister Narendra Modi is a ‘flop show’ when it comes to job creation and not addressing the issue of unemployment. Make in India and Start up India are fake statements. Unemployment is highest in the last 45 years, and this will be huge issue in the coming elections, said Congress President Rahul Gandhi.The party’s focus in the ensuing Lok Sabha elections will be on employment, farmers, and a happy, prosperous and united India, said Gandhi, who was in the city en route to Nagercoil to address a public rally.Economic growth is directly related to the mood of the country. This is something fundamental that the BJP and Modi do not understand. When the country is divided and fighting, States have acrimonious relationships; ‘how can we expect solid economic growth.’’ The first thing the Congress will do (when it comes to power) is bring harmony to the country, he told the media.Job creation will happen through small and medium businesses by transforming them into large businesses. “We will open the banks to these businesses,” he said.Currently, job creators are under assault and attacked by demonetisation and the Goods and Services Tax (GST), which is extremely complicated, and allows a significant amount of ‘rent-seeking’ with Income Tax and other departments having oppressive roles. “We will simplify their lives. We have a phenomenal idea in the election manifesto of making entrepreneurship easy, simple and possible,” he said, adding that the Congress will simply the GST and also lower the tax, if possible.The economy needs to be put on track, and the Congress has a ‘revolutionary’ idea called the Minimum Basic Income guarantee. “I am confident that we will be able to implement it when we come to power. After 2019, there will be nobody in India below the minimum income line; everybody will be brought into that line by a direct cash deposit into their bank accounts,” he said.Gandhi said Modi is turning the demographic dividend into a disaster. There has to be a movement towards unification and building bridges by conversation.Lashing out at Modi for not having an open conversation, Gandhi said, “Don’t have a conversation with me, speak to the press. Have the guts to meet the press and talk to 3,000 students. . Every other Opposition leader is holding a press conference, but Modi is not facing the press, “ he said.On the Rafale controversy, Gandhi said, “we are not questioning the capability of the aircraft but only saying that ‘Modi and Anil Ambani have stolen ₹30,000 crore from the Air Force,” and that there should be an investigation. There will be an investigation and that at the end of it, “Modi and Anil Ambani will be convicted,” he said.The Congress has firmed up alliances in a number of States, including Tamil Nadu, Maharashtra and Jharkhand. Alliance talks in Bihar have practically concluded and are in the final stages in J&K. It is the BJP that does not have alliances,” he said.center_img Slams the BJP for not addressing the issue politics COMMENTS COMMENT SHARE BJPlast_img read more