July 30, 2010 Welcome to the July 25, 2010 Workshop participants! [back from left] Marina Sapunova from Russia, Bruce Ford [scholarship], Christopher Smart [seminar week], Elijah Rushefsky [2 weeks], and Matthew Poot [scholarship]. [front from left] Linda McArdell [2 weeks], Roberta Sassone from Italy, Eva Bauerle from Germany, Marina Cogliani from Italy, Guido Emanuele Fucci from Italy, Youngho Cho from Korea, William Mazerat from France, Pier Domenico Pierandrei from Italy [2 weeks],and Rebecca Robinson from England. [photo & text: Anita Baker]
30Jul Rep. Hauck invites residents to think local during Buy Michigan Week Categories: Hauck News,News Legislator: Local business serves as key cog of state’s economyState Rep. Roger Hauck today encouraged residents in Isabella and Midland Counties to consider buying locally made products and services during Buy Michigan Week – running through Aug. 5.Purchasing goods and services locally creates a positive impact on a region through small business growth, more available jobs and strengthened state and local economies.“Around 50 cents of every dollar spent locally will stay local – helping provide money to our schools, roads, first responders and other areas of need. When that money is not leaving the state, it can make a huge difference on the economic health of our communities,” said Hauck, of Mt. Pleasant. “Michigan has a tremendous track record as a producer, and this week is a great opportunity to bring awareness to what we can do when we invest in our state’s industries as consumers.”In October, the Michigan House passed a resolution supporting “Buy Nearby” – an annual statewide promotion for shopping at local retail outlets instead of alternatives online. The Buy Nearby project estimated that if Michigan residents made a concerted effort to buy locally, an additional $9 billion in economic activity would follow and nearly 74,000 jobs could be created. Up to $2.5 billion in additional wages could be cultivated through the new jobs, per the project’s report.In recognition of their work, Hauck plans on distributing and delivering tributes to local businesses in the area as Buy Michigan Week kicks into gear.
Spanish pay TV operator Canal+ has asked for an independent arbirator to regulate its dispute with Mediapro over the price of football rights supplied under the pair’s contract for the 2012-13 season. Canal+ and Mediapro have been unable to reach agreement on the price of games provided by Mediapro to the pay TV operator, according to a report in newspaper El Pais. Canal+ is also seeking clarifcation over the price to paid for rights to show matches for the next two season.Canal+ and Mediapro reached an agreement last year over the exploitation of rights to the three seasons from 2012-15. Canal+ has said it will continue to pay fees to clubs that have signed with it direct.
Liberty Global CEO, Mike FriesLiberty Global remains committed to the UK market and remains confident about its long-term growth prospects despite hitting a “speed bump” that had contributed to share-price volatility recently, according to president and CEO Mike Fries.Speaking to investors at the company’s annual shareholders meeting, Fries said that after averaging 20% return on equity for the last eight years, “there has been more volatility in our share price than we’re used to and like you we do not like it”.Fries said that some of the volatility was related to the UK market. He said Virgin Media had outperformed the sector, but that it had not met expectations for various reasons.Fries said the conditions that had led to the business delivering a positive return largely continue to exist today “with the exception of Brexit, of course…and movements in inflation and consumer discretionary income”.He said that shareholders had got “a little skittish” about the UK market. He said that the business continued to grow, and this is what investors should focus on. He said that Liberty Global was a relatively heavily leverged business, which contributed to shares volatility on the downside as well as on the upside.“We are about creating value over the long term and…nothing has changed our view,” he said. He said he believed the UK remained a healthily competitive and “rational” market.“I would characterise this as a speed bump,” he said, rather than a major obstacle to growth.Answering a question on Brexit, Fries said that there had been “no direct impact as such” but that the economic indicators were moving possibly in the wrong direction to some extent, with inflation up and discretionary spending down. He said Liberty wanted to “give people more for more”, increasing prices as it improved its offering.Fries said that Virgin Media is “not hunkering down or playing defence”. He said it was investing in products and delivering higher speeds, was investing in quad-play through building a substantial mobile play, was focusing on realising efficiency and “most important, expanding our footprint” to reach an additional homes.Fries said that there had been good results through to the end of Q1 from Project Lightning, the Virgin Media network expansion project, with higher RGUs and new customers.Fries said that Liberty Global had “retooled” the project following problems that had let to the number of homes connected being overstated at the start of this year, and changed management where necessary, as well as revising the company’s go-to-market approach. He said that penetration in new build areas was meeting expectations.Fries said that Liberty Global has continued to grow in other European markets.Referring to Liberty’s plans in the Latin American and Caribbean market, where it has acquired Caribbean operator CWC, Fries said that the company had revamped CWC’s management and turned things around quickly. He said he was still hopeful that the overall Latin American business could be spun off by the end of this year. The company is currently traded via a tracking stock.Fries said that there would be considerable opportunities to grow in the Latin American and Caribbean region through acquisition, and having a separate stock market listing would enable this. He said that there would nevertheless be close cooperation between the Latin American business and Europe, particularly over things such as procurement.Answering a question on CWC, Fries said that “the business that was handed over to us” wasn’t quite as promised, and Liberty had to restate some of its accounts. “It is a complicated business. We love the underlying opportunity,” he said, in a region with low broadband penetration.Fries said that Liberty had always been focused on creating long-term shareholder value, despite short-term issues.He said that Liberty was capable of innovating at a speed that would keep it ahead of the competition. He said Liberty Global was on track to continue delivering cash after 48 straight quarters of continued cash-flow growth.
In the context of neurodegenerative diseases such as Alzheimer’s, activating LANDO in microglial cells could prove to be therapeutically beneficial through increased clearance of β-amyloid and mitigation of neuroinflammation.”Corresponding author Douglas Green, Ph.D., chair of the St. Jude Department of Immunology Reviewed by James Ives, M.Psych. (Editor)Jun 28 2019St. Jude Children’s Research Hospital scientists have discovered a pathway that functions like a car wash to prevent the buildup of a toxic protein associated with Alzheimer’s disease. The report appeared online today in the journal Cell.The findings in a mouse model of Alzheimer’s offer a possible new approach to treatment of the chronic neurodegenerative disorder, which is the sixth leading cause of death in the U.S. The newly identified pathway also helps regulate inflammation, so the discovery could yield strategies for unleashing the immune response against malignant brain tumors.Researchers called the pathway LC3-associated endocytosis or LANDO. They found the pathway in microglial cells, the primary immune cells of the brain and central nervous system. However, preliminary evidence suggests LANDO is a fundamental process that functions in cells throughout the body.Investigators showed that LANDO protected against deposits of neurotoxic β-amyloid protein in mice. Activation of the pathway also guarded against toxic neuroinflammation and neurodegeneration, including memory problems. While activation of LANDO appears to protect against neurodegenerative disease, first author Bradlee Heckmann, Ph.D., a postdoctoral fellow in Green’s laboratory, said inhibiting the pathway might boost the effectiveness of cancer immunotherapy. “Although in its infancy, preliminary data using a primary brain tumor model suggests that inhibition of LANDO might provide a mechanism to activate inflammation within the tumor microenvironment to generate an anti-tumor response,” Heckmann said.Car washRelated StoriesRNA-binding protein SRSF3 appears to be key factor for proper heart contraction, survivalVirus killing protein could be the real antiviral hero finds studyHinge-like protein may unlock new pathways for cystic fibrosis treatmentβ-amyloid protein accumulation in neurons is a hallmark of Alzheimer’s. Scientists knew microglial cells take up β-amyloid proteins. Discovery of the LANDO pathway answers questions about what comes next.Heckmann compared LANDO to the operator of an automatic carwash. In this case, the cars are the receptors on the microglial cells that bind to neurotoxic β-amyloid proteins and bring the protein into the car wash. And, just as cars return to the streets after the dirt is gone, when the β-amyloid is disposed of, the receptor returns to the microglial surface where it can pick up additional β-amyloid.An automatic car wash depends on hardware to attach the car to a track that moves it through the machine. Similarly, several proteins are required for LANDO functioning. The proteins–Rubicon, Beclin 1, ATG5 and ATG7–are better known for their roles in a related cell pathway used to recycle unneeded and unwanted cell components. These proteins decline with age as their expression decreases.Follow the data”You never know where science will lead,” Green said. “This project started because we were studying immune responses against cancer. Brad recognized the findings had relevance to a disease not of children but of older people.”That’s how science works. When you follow the data, you never know where it will lead.” Source:St. Jude Children’s Research HospitalJournal reference:Green, D.R. et al. (2019) LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease. Cell. doi.org/10.1016/j.cell.2019.05.056.
Next Army gears up for worsening floods in Assam A reserve of 95 flood relief columns along with additional 31 columns have been kept on stand by, in view of the worsening flood situation in the Eastern region.advertisement Manjeet Singh Negi New DelhiJuly 16, 2019UPDATED: July 16, 2019 17:20 IST Army has alerted flood relief columns to be prepared for deployment on short noticeA reserve of 95 flood relief columns along with additional 31 columns have been kept on stand by, in view of the worsening flood situation in the Eastern region.Lieutenant General MM Naravane, General Officer Commanding-in-Chief, Eastern Command, took stock of the situation and assured a quick response by the Army on being requisitioned for deployment on flood relief tasks.The Army is closely monitoring the flood situation in close coordination with civil administration in flood-prone areas. There are 152 monitoring stations which will ensure timely warning of an impending crisis due to floods.Army has alerted flood relief columns to be prepared for deployment on short notice. Mock drills conducted by the nominated army units in the run-up to the monsoon will ensure seamless integration of all elements and their synergized application in support of the populace.Floodwaters in Assam rose overnight with the Brahmaputra River, which flows down from the Himalayas into Bangladesh, and its tributaries still in spate. Most of the Kaziranga National Park, home to the rare one-horned rhino, was underwater, authorities in Assam said, adding that four people drowned on Monday.The flood situation has turned very critical with 31 of the 32 districts affected, Assam Chief Minister Sarbananda Sonowal told reporters. We are working on a war footing to deal with the flood situation.Assam, known for its tea industry, is hit by seasonal flooding each year, and the state and federal governments have spent millions of rupees on flood control.Army and paramilitary personnel have been deployed across the state for rescue and relief operations and makeshift shelter camps have been set up, while the airforce is on standby.ALSO READ: Nearly 70 lakh affected in floods in Bihar, northeast India; toll mounts to 44ALSO WATCH: Assam flood death toll reaches 11, Barpeta worst affected districtFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byShreya Sinha
Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoHealthCentral.com7 Sneaky Signs of Lung CancerHealthCentral.comUndoYahoo SearchYou’ve Never Seen Luxury Like This On A Cruise Ship. Search Luxury Mediterranean CruisesYahoo SearchUndoNature's BlendNever Let Your Dog Eat These 3 FoodsNature’s BlendUndo Colorful But Deadly: Images of Brain Cancer 7 Odd Things That Raise Your Risk of Cancer (and 1 That Doesn’t) 7 Side Effects of Cancer Treatment, and How to Cope with Them A simple cold virus could wipe out tumors in a form of bladder cancer, a small new study suggests. Though the idea of using viruses to fight cancer isn’t new, this is the first time a cold virus effectively treated an early-stage form of bladder cancer. In one patient, it eliminated a cancerous tumor, the group reported July 4 in the journal Clinical Cancer Research. A group of researchers conducted an early-stage clinical trial in which they infected 15 bladder cancer patients with coxsackievirus A21, which is one of the viruses that cause the common cold. Coxsackievirus is not a genetically modified virus; it’s “something that occurs in nature,” said senior author Hardev Pandha, a professor of medical oncology at the University of Surrey in England. [Exercise May Reduce the Risk of These 13 Cancers]Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65908-cold-virus-might-treat-bladder-cancer.html?jwsource=cl已复制直播00:0000:3500:35 The researchers gave the patients the virus through catheters that the patients already had inserted for other treatments. They left the virus-filled catheter in for an hour to pump the fluids into the bladder and repeated this treatment. Then, the patients underwent surgery to remove what was left of their bladder tumors. In one patient, the virus completely destroyed the tumor. In all of the other patients, the researchers found evidence that the virus had damaged the tumors and had spurred the immune system to send an army of immune cells to the tumors. None of the patients had any significant side effects, Pandha said. Researchers thought this method would work because the outer membranes of cancerous bladder cells contain a gateway for the coxsackievirus: a molecule called ICAM-1. Because healthy cells don’t carry this molecule, the coxsackievirus doesn’t attack them. Once the virus gets into the cell, it hijacks the cell’s machinery and ends up killing it. Even more cancer cells die when the immune cells are recruited. ICAM-1 is also expressed by other cancer cells, and coxsackievirus has, in fact been previously shown to be effective in treating very advanced bladder cancer and other cancers, such as melanoma, Pandha said. Even so, this is still an early-stage trial, and there’s still a long way to go before the method can be used in treatment, Pandha said. “This would be the foundation for much larger studies where we’d build on this,” he said. Newer studies will try to make the treatment more effective and stop the cancer from coming back, he added. Unfortunately, just getting a common cold won’t treat the cancer on its own. Pandha’s team gave a much higher dose of the virus than you would get if someone coughed on you and you got sick, for example. Interestingly, the patients who were given the virus through the catheter did not get cold symptoms. “I agree that [such viruses are] good therapeutic target[s]” for certain types of cancers, like bladder cancer, said Grant McFadden, director of the Biodesign Center for Immunotherapy, Vaccines and Virotherapy at Arizona State University, who was not a part of the study. But he noted that many studies have looked at whether viruses can target cancer cells. In fact, a host of viruses have been studied for attacking bladder cancer, specifically. It’s likely that many viruses will work well to treat bladder cancer and at least some tumor-destroying viruses “will get approved for use in humans,” McFadden told Live Science. “But this paper isn’t really new or innovative.” In fact, the idea of using viruses to treat cancer goes back nearly 100 years, Pandha said, but only in the past decade or so has it gained momentum. Editor’s note: This article was updated. Only a couple of the authors (not Pandha) are employed by Viralytics, a Merck-owned biotech company that is developing viral-based cancer treatments.