Tag: 上海419论坛YF

This celebrity cat has broken the internet Now we have its genome

first_img Leslie Lyons Click to view the privacy policy. Required fields are indicated by an asterisk (*) Orsolya Symmons Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe Leslie Lyons Q: Whose idea was this project?O.S.: Darío and Daniel, the other two lead authors, were watching a documentary with Lil Bub, and they were like, “This is incredibly interesting. What might cause Bub to look like that? Do we know the genetics behind it?” So they had the scientific idea, but we knew it might be difficult to finance. Because I had a background in blogging, and because Bub is so popular, we thought we could try crowdfunding.L.L.: For good or for bad, celebrities attract attention, whether it’s human celebrities or animal celebrities. We’ve tried to get other celebrity cats to jump on board before, but Lil Bub was the bravest of them all.Q: How did you get Lil Bub’s owners involved?O.S.: Daniel and Dario reached out to Mike, the owner of Bub, and he’s incredibly open and super excited about everything Bub-related. He’s not a scientist, so throughout the whole process we were keeping in touch and breaking everything down for him about what we were finding and why it was interesting.Q: Were you surprised by the findings?L.L.: At first, you’re thinking Lil Bub’s polydactyly and her limb shortness are all part of the same syndrome. Then you start to tease it apart and you realize, no, she has Sonic hedgehog mutations that have nothing to do with the [osteopetrosis] issue that’s going on. It was like, “Wow, that’s kind of weird, the cat has two different rare mutations.” This celebrity cat has broken the internet. Now, we have its genome Orsolya Symmons Cats may rule the internet, but few felines have achieved the online fame of Lil Bub. Discovered as a feral kitten outside Bloomington, Indiana, in 2011, she had a series of congenital abnormalities: extra toes, shorter-than-usual limbs, and a tongue that perpetually hangs out of her mouth. For owner Mike Bridavsky—and Lil Bub’s millions of internet fans—these peculiarities just made her more lovable.For years, Lil Bub has been a spokescat for animal shelters, helping her furry brethren find homes of their own. Now, she’s helping scientists, too. This week—thanks to a crowdfunding effort that raised more than $8000 on Experiment.com—geneticists led by Darío Lupiáñez of the Max-Delbrück Center for Molecular Medicine in Berlin, Daniel Ibrahim of the Max Planck Institute for Molecular Genetics in Berlin, and Orsolya Symmons of the University of Pennsylvania—have sequenced Lil Bub’s whole genome.The researchers discovered two telltale genetic abnormalities, they report on the preprint server bioRxiv. Lil Bub owes her extra toes to a somewhat common genetic variation in a stretch of DNA that acts as an “on-off switch” for the Sonic hedgehog gene, also responsible for Ernest Hemingway’s famously polydactyl cats, whose six-toed progeny still roam his former home in Key West, Florida. The other key gene was more surprising: a variation of TNFRSF11A, a gene known from mice and humans to be associated with a rare condition called osteopetrosis, which causes unusually dense bones and short stature.center_img The preprint has already drawn amused attention from some scientists, with one tweeting, “Very jealous this wasn’t my Ph.D. project” and another writing, “Comparative Genomics of Internet Cats is a Keystone Conference I look forward to attending.”Science discussed the findings with Symmons and co-author Leslie Lyons, an expert on cat genetics at the University of Missouri in Columbia and founder of the 99 Lives Cat Genome Sequencing Initiative. The interview has been edited for clarity and length. Ronen Tivony/NurPhoto/Getty Images By Michael PriceFeb. 26, 2019 , 6:35 PM Sign up for our daily newsletter Get more great content like this delivered right to you! Country Researchers found that feline internet celebrity Lil Bub owes her unique appearance to a rare genetic disease known in humans as osteopetrosis. Email Q: Why is this discovery important?O.S.: Nobody had ever described this type of genetic osteopetrosis in cats, but there are very similar mutations in the same gene in mice and in humans that also cause osteopetrosis.L.L.: Humans have this disease, too, and knowing more about how this mutation functions might help lead to a tailored therapy with precision medicine that affects the gene.It also shows why animal genetics is important. In human genetics, there’s a still a huge number of variants of unknown significance, which basically means you don’t know if they’re benign or not. That’s one of the things our project is trying to do. If you look at the genetic information in cats and dogs, that might tell you a particular mutation is found all the time in cats and they’re perfectly fine, so it probably is a benign mutation.Q: What’s next for your work?O.S.: When you mention you have a crowdfunded celebrity cat project, people don’t necessarily take the science seriously, but it is a serious scientific project. It would be great to get it published. That’s partially why we put it out on bioRxiv, to get some peer feedback in case we missed anything really obvious.Also, because we’ve put it out in the public domain, we’re hoping that anyone who’s interested in it can do what they want and see where they can take this. We’ve seen a lot of tweets so far from teachers who say they plan to use this in their classrooms. We’re kind of hoping this takes on a life of its own.L.L.: I hope this shows the importance of funding cat research. Here’s something that was hard to get funded—that they had to go beg the crowd to get funding for—and it comes up with a very important biological consequence. In the end, it’s not a gimmick. It’s how we’ve had to struggle in the cat world to do good science.*Correction, 27 February, 10:15 a.m.: This story has been updated to note that Lil Bub’s polydactylism is due to a variation in a stretch of DNA that modulates activity in the Sonic hedgehog gene.last_img read more